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Semin Respir Crit Care Med 2012; 33(01): 96-110
DOI: 10.1055/s-0032-1301738
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Acute Respiratory Failure Complicating Advanced Liver Disease

Marcin Karcz
1   Department of Anesthesiology, University of Rochester School of Medicine, Rochester, New York.
,
Bridget Bankey
1   Department of Anesthesiology, University of Rochester School of Medicine, Rochester, New York.
,
David Schwaiberger
3   Department of Anesthesiology and Operative Intensive Care, Campus Virchow Klinikum Charite, Berlin, Germany.
,
Burkhard Lachmann
3   Department of Anesthesiology and Operative Intensive Care, Campus Virchow Klinikum Charite, Berlin, Germany.
,
Peter J. Papadakos
1   Department of Anesthesiology, University of Rochester School of Medicine, Rochester, New York.
2   Department of Surgery and Neurosurgery, University of Rochester School of Medicine, Rochester, New York.
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Publikationsverlauf

Publikationsdatum:
23. März 2012 (online)

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Abstract

Advanced liver disease is associated with hypoxemia and respiratory failure by various mechanisms. Patients with cirrhosis are especially prone to episodes of decompensation requiring intensive care unit admission and management. Such patients may already be in acute liver failure or have decompensated due to a concurrent illness such as spontaneous bacterial peritonitis, sepsis, encephalopathy, varices, or hepatorenal syndrome. Acute respiratory distress syndrome is one of the main reasons for intensive care unit admission and mortality. Overall, critically ill cirrhotic patients frequently progress to multiorgan failure requiring mechanical ventilation. Caring for such patients is therefore understandably complex and extremely challenging. Patients with end-stage liver disease are especially at risk for developing acute respiratory failure and hypoxemia secondary to hepatopulmonary syndrome, portopulmonary hypertension, and hepatic hydrothorax. They should therefore be screened for these conditions because failure to recognize and adequately treat these serious complications of cirrhosis may have devastating consequences. This article is based on a review of the current literature on how to approach and manage acute respiratory failure in advanced liver disease, which is important to intensivists, anesthesiologists, and physicians as a whole.

Keywords

respiratory failure - cirrhosis - acute respiratory distress syndrome - hepatopulmonary syndrome - portopulmonary hypertension - hepatic hydrothorax
 

  • References

  • 1 Young-Hee Y, Hsiao-ye Y . Liver cirrhosis mortality in the United States, 1970–2007. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism; August 2010 http://pubs.niaaa.nih.gov/publications/surveillance88/cirr07.htm . Accessed July 1, 2011
    PubMed
  • 2 D’Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006; 44 (1) 217-231
    CrossrefPubMedGoogle Scholar
  • 3 Agusti AGN, Roca J, Rodriguez-Roisin R. Mechanisms of gas exchange impairment in patients with liver cirrhosis. Clin Chest Med 1996; 17 (1) 49-66
    CrossrefPubMedGoogle Scholar
  • 4 Chao Y, Wang SS, Lee SD, Shiao GM, Chang HI, Chang SC. Effect of large-volume paracentesis on pulmonary function in patients with cirrhosis and tense ascites. J Hepatol 1994; 20 (1) 101-105
    PubMedGoogle Scholar
  • 5 Angueira CE, Kadakia SC. Effects of large-volume paracentesis on pulmonary function in patients with tense cirrhotic ascites. Hepatology 1994; 20 (4 Pt 1) 825-828
    PubMedGoogle Scholar
  • 6 Agustí AGN, Roca J, Bosch J, Rodriguez-Roisin R. The lung in patients with cirrhosis. J Hepatol 1990; 10 (2) 251-257
    CrossrefPubMedGoogle Scholar
  • 7 Krowka MJ, Cortese DA. Pulmonary aspects of chronic liver disease and liver transplantation. Mayo Clin Proc 1985; 60 (6) 407-418
    CrossrefPubMedGoogle Scholar
  • 8 Møller S, Hillingsø J, Christensen E, Henriksen JH. Arterial hypoxaemia in cirrhosis: fact or fiction?. Gut 1998; 42 (6) 868-874
    CrossrefPubMedGoogle Scholar
  • 9 Martínez GP, Barberà JA, Visa J , et al. Hepatopulmonary syndrome in candidates for liver transplantation. J Hepatol 2001; 34 (5) 651-657
    PubMedGoogle Scholar
  • 10 Hourani JM, Bellamy PE, Tashkin DP, Batra P, Simmons MS. Pulmonary dysfunction in advanced liver disease: frequent occurrence of an abnormal diffusing capacity. Am J Med 1991; 90 (6) 693-700
    PubMedGoogle Scholar
  • 11 Naeije R, Mélot C, Hallemands R, Mols P, Lejeune P. Pulmonary hemodynamics in liver cirrhosis. Semin Respir Med 1985; 7: 164-170
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 12 Keys A, Snell AM. Respiratory properties of the arterial blood in normal men and in patients with disease of the liver: position of the oxygen dissociation curve. J Clin Invest 1938; 17 (1) 59-67
    CrossrefPubMedGoogle Scholar
  • 13 Caldwell PRB, Fritts Jr HW, Cournand A. Oxyhemoglobin dissociation curve in liver cirrhosis. J Appl Physiol 1965; 20: 316-320
    PubMedGoogle Scholar
  • 14 Zimmon DS. Oxyhemoglobin dissociation in patients with hepatic encephalopathy. Gastroenterology 1967; 52 (4) 647-654
    PubMedGoogle Scholar
  • 15 Astrup J, Rörth M. Oxygen affinity of hemoglobin and red cell 2,3-diphosphoglycerate in hepatic cirrhosis. Scand J Clin Lab Invest 1973; 31 (3) 311-317
    CrossrefPubMedGoogle Scholar
  • 16 Heinemann HO, Emirgil C, Mijnssen JP. Hyperventilation and arterial hypoxemia in cirrhosis of the liver. Am J Med 1960; 28: 239-246
    CrossrefPubMedGoogle Scholar
  • 17 Rodman T, Sobel M, Close HP. Arterial oxygen unsaturation and the ventilation-perfusion defect of Laennec's cirrhosis. N Engl J Med 1960; 263: 73-77
    CrossrefPubMedGoogle Scholar
  • 18 Karetzky MS, Mithoefer JC. The cause of hyperventilation and arterial hypoxia in patients with cirrhosis of the liver. Am J Med Sci 1967; 254 (6) 797-804
    CrossrefPubMedGoogle Scholar
  • 19 Abelman WH, Kramer GE, Verstraeten JM , et al. Cirrhosis of the liver and decreased arterial oxygen saturation. Arch Intern Med 1961; 108: 102-108
    PubMedGoogle Scholar
  • 20 Massumi RA, Rios JC, Ticktin HE. Hemodynamic abnormalities and venous admixture in portal cirrhosis. Am J Med Sci 1965; 250 (3) 275-283
    CrossrefPubMedGoogle Scholar
  • 21 Mellemgaard K, Winkler K, Tygstrup N, Georg J. Sources of venoarterial admixture in portal hypertension. J Clin Invest 1963; 42: 1399-1405
    CrossrefPubMedGoogle Scholar
  • 22 Wilson RH, Ebert RV, Borden CW , et al. The determinations of blood flow through nonventilated portions of the normal and diseased lung. Am Rev Tuberc 1953; 68 (2) 177-187
    PubMedGoogle Scholar
  • 23 Fritts Jr HW, Hardewig A, Rochester DF, Durand J, Cournand A. Estimation of pulmonary arteriovenous shunt-flow using intravenous injections of T-1824 dye and Kr85. J Clin Invest 1960; 39: 1841-1850
    CrossrefPubMedGoogle Scholar
  • 24 Eriksson LS, Söderman C, Ericzon BG, Eleborg L, Wahren J, Hedenstierna G. Normalization of ventilation/perfusion relationships after liver transplantation in patients with decompensated cirrhosis: evidence for a hepatopulmonary syndrome. Hepatology 1990; 12 (6) 1350-1357
    CrossrefPubMedGoogle Scholar
  • 25 Hedenstierna G, Söderman C, Eriksson LS, Wahren J. Ventilation-perfusion inequality in patients with non-alcoholic liver cirrhosis. Eur Respir J 1991; 4 (6) 711-717
    PubMedGoogle Scholar
  • 26 Hervé P, Lebrec D, Brenot F , et al. Pulmonary vascular disorders in portal hypertension. Eur Respir J 1998; 11 (5) 1153-1166
    CrossrefPubMedGoogle Scholar
  • 27 Møller S, Becker U, Schifter S, Abrahamsen J, Henriksen JH. Effect of oxygen inhalation on systemic, central, and splanchnic haemodynamics in cirrhosis. J Hepatol 1996; 25 (3) 316-328
    CrossrefPubMedGoogle Scholar
  • 28 Söderman C, Eriksson LS, Juhlin-Dannfelt A, Lundberg JM, Broman L, Holmgren A. Effect of vasoactive intestinal polypeptide (VIP) on pulmonary ventilation-perfusion relationships and central haemodynamics in healthy subjects. Clin Physiol 1993; 13 (6) 677-685
    CrossrefPubMedGoogle Scholar
  • 29 Söderman C, Juhlin-Dannfelt A, Lagerstrand L, Eriksson LS. Ventilation-perfusion relationships and central haemodynamics in patients with cirrhosis: effects of a somatostatin analogue. J Hepatol 1994; 21 (1) 52-57
    CrossrefPubMedGoogle Scholar
  • 30 Rodriguez-Roisin R, Roca J, Agusti AGN, Mastai R, Wagner PD, Bosch J. Gas exchange and pulmonary vascular reactivity in patients with liver cirrhosis. Am Rev Respir Dis 1987; 135 (5) 1085-1092
    PubMedGoogle Scholar
  • 31 Mélot C, Naeije R, Dechamps P, Hallemans R, Lejeune P. Pulmonary and extrapulmonary contributors to hypoxemia in liver cirrhosis. Am Rev Respir Dis 1989; 139 (3) 632-640
    PubMedGoogle Scholar
  • 32 Ruff F, Hughes JMB, Stanley N , et al. Regional lung function in patients with hepatic cirrhosis. J Clin Invest 1971; 50 (11) 2403-2413
    CrossrefPubMedGoogle Scholar
  • 33 Daoud FS, Reeves JT, Schaefer JW. Failure of hypoxic pulmonary vasoconstriction in patients with liver cirrhosis. J Clin Invest 1972; 51 (5) 1076-1080
    CrossrefPubMedGoogle Scholar
  • 34 Krowka MJ. Hepatopulmonary syndromes. Gut 2000; 46 (1) 1-4
    CrossrefPubMedGoogle Scholar
  • 35 Fallon MB, Abrams GA. Pulmonary dysfunction in chronic liver disease. Hepatology 2000; 32 (4 Pt 1) 859-865
    CrossrefPubMedGoogle Scholar
  • 36 Cotes JE, Chinn DJ, Quanjer PH, Roca J, Yernault JC ; Official Statement of the European Respiratory Society. Standardization of the measurement of transfer factor (diffusing capacity). Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Eur Respir J Suppl 1993; 16: 41-52
    PubMedGoogle Scholar
  • 37 Møller S, Burchardt H, Øgard CG, Schiødt FV, Lund JO. Pulmonary blood volume and transit time in cirrhosis: relation to lung function. Liver Int 2006; 26 (9) 1072-1078
    CrossrefPubMedGoogle Scholar
  • 38 Katsuta Y, Honma H, Zhang XJ , et al. Pulmonary blood transit time and impaired arterial oxygenation in patients with chronic liver disease. J Gastroenterol 2005; 40 (1) 57-63
    CrossrefPubMedGoogle Scholar
  • 39 Gómez FP, Martínez-Pallí G, Barberà JA, Roca J, Navasa M, Rodríguez-Roisin R. Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome. Hepatology 2004; 40 (3) 660-666
    PubMedGoogle Scholar
  • 40 Singh N, Gayowski T, Wagener MM, Marino IR. Outcome of patients with cirrhosis requiring intensive care unit support: prospective assessment of predictors of mortality. J Gastroenterol 1998; 33 (1) 73-79
    CrossrefPubMedGoogle Scholar
  • 41 Kress JP, Rubin A, Pohlman AS, Hall JB. Outcomes of critically ill patients denied consideration for liver transplantation. Am J Respir Crit Care Med 2000; 162 (2 Pt 1) 418-423
    PubMedGoogle Scholar
  • 42 Aggarwal A, Ong JP, Younossi ZM, Nelson DR, Hoffman-Hogg L, Arroliga AC. Predictors of mortality and resource utilization in cirrhotic patients admitted to the medical ICU. Chest 2001; 119 (5) 1489-1497
    CrossrefPubMedGoogle Scholar
  • 43 Levy MF, Greene L, Ramsay MA , et al. Readmission to the intensive care unit after liver transplantation. Crit Care Med 2001; 29 (1) 18-24
    CrossrefPubMedGoogle Scholar
  • 44 Ramachandran A, Balasubramanian KA. Intestinal dysfunction in liver cirrhosis: its role in spontaneous bacterial peritonitis. J Gastroenterol Hepatol 2001; 16 (6) 607-612
    CrossrefPubMedGoogle Scholar
  • 45 Westphal J-F, Jehl F, Vetter D. Pharmacological, toxicologic, and microbiological considerations in the choice of initial antibiotic therapy for serious infections in patients with cirrhosis of the liver. Clin Infect Dis 1994; 18 (3) 324-335
    CrossrefPubMedGoogle Scholar
  • 46 Przybyłowski T, Krenke R, Fangrat A , et al. Gas exchange abnormalities in patients listed for liver transplantation. J Physiol Pharmacol 2006; 57 (Suppl 4) 313-323
    PubMedGoogle Scholar
  • 47 Mohamed R, Freeman JW, Guest PJ, Davies MK, Neuberger JM. Pulmonary gas exchange abnormalities in liver transplant candidates. Liver Transpl 2002; 8 (9) 802-808
    CrossrefPubMedGoogle Scholar
  • 48 Johnson DH, Cunha BA. Infections in cirrhosis. Infect Dis Clin North Am 2001; 15 (2) 363-371, vii
    CrossrefPubMedGoogle Scholar
  • 49 Wallaert B, Aerts C, Colombel JF, Voisin C. Human alveolar macrophage antibacterial activity in the alcoholic lung. Am Rev Respir Dis 1991; 144 (2) 278-283
    CrossrefPubMedGoogle Scholar
  • 50 Gosset P, Wallaert B, Canva-Delcambre V, Colombel JF, Tonnel AB. Impaired secretion and mRNA expression of monokines by alveolar macrophages from nonsmoking patients with alcoholic liver cirrhosis. J Infect Dis 1995; 171 (3) 743-746
    CrossrefPubMedGoogle Scholar
  • 51 Wallaert B, Colombel JF, Prin L, Sibille Y, Tonnel AB. Bronchoalveolar lavage in alcoholic liver cirrhosis. T-lymphocyte subsets and immunoglobulin concentrations. Chest 1992; 101 (2) 468-473
    CrossrefPubMedGoogle Scholar
  • 52 Doyle HR, Marino IR, Miro A , et al. Adult respiratory distress syndrome secondary to end-stage liver disease-successful outcome following liver transplantation. Transplantation 1993; 55 (2) 292-296
    CrossrefPubMedGoogle Scholar
  • 53 Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med 1995; 152 (6 Pt 1) 1818-1824
    CrossrefPubMedGoogle Scholar
  • 54 TenHoor T, Mannino DM, Moss M. Risk factors for ARDS in the United States: analysis of the 1993 National Mortality Followback Study. Chest 2001; 119 (4) 1179-1184
    CrossrefPubMedGoogle Scholar
  • 55 Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132 (3) 485-489
    PubMedGoogle Scholar
  • 56 Fowler AA, Hamman RF, Zerbe GO, Benson KN, Hyers TM. Adult respiratory distress syndrome. Prognosis after onset. Am Rev Respir Dis 1985; 132 (3) 472-478
    PubMedGoogle Scholar
  • 57 Seidenfeld JJ, Pohl DF, Bell RC, Harris GD, Johanson Jr WG. Incidence, site, and outcome of infections in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1986; 134 (1) 12-16
    PubMedGoogle Scholar
  • 58 Hyers TM, Fowler AA. Adult respiratory distress syndrome: causes, morbidity, and mortality. Fed Proc 1986; 45 (1) 25-29
    PubMedGoogle Scholar
  • 59 Phua J, Badia JR, Adhikari NK , et al. Has mortality from acute respiratory distress syndrome decreased over time?: a systematic review. Am J Respir Crit Care Med 2009; 179 (3) 220-227
    CrossrefPubMedGoogle Scholar
  • 60 Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest 2008; 133 (5) 1120-1127
    CrossrefPubMedGoogle Scholar
  • 61 Cholongitas E, Senzolo M, Patch D , et al. Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit. Aliment Pharmacol Ther 2006; 23 (7) 883-893
    CrossrefPubMedGoogle Scholar
  • 62 Das V, Boelle PY, Galbois A , et al. Cirrhotic patients in the medical intensive care unit: early prognosis and long-term survival. Crit Care Med 2010; 38 (11) 2108-2116
    CrossrefPubMedGoogle Scholar
  • 63 Findlay JY, Fix OK, Paugam-Burtz C , et al. Critical care of the end-stage liver disease patient awaiting liver transplantation. Liver Transpl 2011; 17 (5) 496-510
    CrossrefPubMedGoogle Scholar
  • 64 Matuschak GM, Rinaldo JE, Pinsky MR , et al. Effects of end-stage liver failure on the incidence and resolution of the adult respiratory distress syndrome. J Crit Care 1987; 2: 162-173
    CrossrefPubMedGoogle Scholar
  • 65 Monchi M, Bellenfant F, Cariou A , et al. Early predictive factors of survival in the acute respiratory distress syndrome: a multivariate analysis. Am J Respir Crit Care Med 1998; 158 (4) 1076-1081
    PubMedGoogle Scholar
  • 66 Rouby JJ, Puybasset L, Cluzel P, Richecoeur J, Lu Q, Grenier P ; CT Scan ARDS Study Group. Regional distribution of gas and tissue in acute respiratory distress syndrome, II: Physiological correlations and definition of an ARDS Severity Score. Intensive Care Med 2000; 26 (8) 1046-1056
    CrossrefPubMedGoogle Scholar
  • 67 Gattinoni L, Caironi P, Pelosi P, Goodman LR. What has computed tomography taught us about the acute respiratory distress syndrome?. Am J Respir Crit Care Med 2001; 164 (9) 1701-1711
    CrossrefPubMedGoogle Scholar
  • 68 Pelosi P, D’Andrea L, Vitale G, Pesenti A, Gattinoni L. Vertical gradient of regional lung inflation in adult respiratory distress syndrome. Am J Respir Crit Care Med 1994; 149 (1) 8-13
    PubMedGoogle Scholar
  • 69 Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ ; The CT Scan ARDS Study Group. A computed tomography scan assessment of regional lung volume in acute lung injury. Am J Respir Crit Care Med 1998; 158 (5 Pt 1) 1644-1655
    PubMedGoogle Scholar
  • 70 Matuschak GM, Rinaldo JE. Organ interactions in the adult respiratory distress syndrome during sepsis: role of the liver in host defense. Chest 1988; 94 (2) 400-406
    CrossrefPubMedGoogle Scholar
  • 71 Bell RC, Coalson JJ, Smith JD, Johanson Jr WG. Multiple organ system failure and infection in adult respiratory distress syndrome. Ann Intern Med 1983; 99 (3) 293-298
    PubMedGoogle Scholar
  • 72 Matuschak GM. Lung-liver interactions in sepsis and multiple organ failure syndrome. Clin Chest Med 1996; 17 (1) 83-98
    CrossrefPubMedGoogle Scholar
  • 73 Ruiter DJ, van der Meulen J, Brouwer A , et al. Uptake by liver cells of endotoxin following its intravenous injection. Lab Invest 1981; 45 (1) 38-45
    PubMedGoogle Scholar
  • 74 Saldeen T. Clotting, microembolism, and inhibition of fibrinolysis in adult respiratory distress. Surg Clin North Am 1983; 63 (2) 285-304
    PubMedGoogle Scholar
  • 75 Bradfield JWB. Control of spillover: the importance of Kupffer-cell function in clinical medicine. Lancet 1974; 2 (7885) 883-886
    PubMedGoogle Scholar
  • 76 Wardle EN. Kupffer cells and their function. Liver 1987; 7 (2) 63-75
    PubMedGoogle Scholar
  • 77 Yokoyama I, Todo S, Miyata T, Selby R, Tzakis AG, Starzl TE. Endotoxemia and human liver transplantation. Transplant Proc 1989; 21 (5) 3833-3841
    PubMedGoogle Scholar
  • 78 Miyata T, Yokoyama I, Todo S, Tzakis A, Selby R, Starzl TE. Endotoxaemia, pulmonary complications, and thrombocytopenia in liver transplantation. Lancet 1989; 2 (8656) 189-191
    PubMedGoogle Scholar
  • 79 Altomare E, Vendemiale G, Albano O. Hepatic glutathione content in patients with alcoholic and non alcoholic liver diseases. Life Sci 1988; 43 (12) 991-998
    CrossrefPubMedGoogle Scholar
  • 80 Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LA. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am J Respir Crit Care Med 2000; 161 (2 Pt 1) 414-419
    PubMedGoogle Scholar
  • 81 Rahman Q, Abidi P, Afaq F , et al. Glutathione redox system in oxidative lung injury. Crit Rev Toxicol 1999; 29 (6) 543-568
    CrossrefPubMedGoogle Scholar
  • 82 Kaplan JE, Saba TM. Platelet removal from the circulation by the liver and spleen. Am J Physiol 1978; 235 (3) H314-H320
    PubMedGoogle Scholar
  • 83 Matuschak GM, Pinsky MR, Klein EC, Van Thiel DH, Rinaldo JE. Effects of D-galactosamine-induced acute liver injury on mortality and pulmonary responses to Escherichia coli lipopolysaccharide. Modulation by arachidonic acid metabolites. Am Rev Respir Dis 1990; 141 (5 Pt 1) 1296-1306
    PubMedGoogle Scholar
  • 84 Goldfarb G, Nouel O, Poynard T, Rueff B. Efficiency of respiratory assistance in cirrhotic patients with liver failure. Intensive Care Med 1983; 9 (5) 271-273
    CrossrefPubMedGoogle Scholar
  • 85 Lee KC, Chiang AA. The outcome of terminal liver cirrhosis patients requiring mechanical ventilation. Zhonghua Yi Xue Za Zhi (Taipei) 1997; 59 (2) 88-94
    PubMedGoogle Scholar
  • 86 Moreau R, Hadengue A, Soupison T , et al. Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome. Crit Care Med 1992; 20 (6) 746-750
    CrossrefPubMedGoogle Scholar
  • 87 Shellman RG, Fulkerson WJ, DeLong E, Piantadosi CA. Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit. Crit Care Med 1988; 16 (7) 671-678
    CrossrefPubMedGoogle Scholar
  • 88 Castera L, Pauwels A, Lévy VG. Prognostic indicators in patients with liver cirrhosis admitted to an intensive care unit [in French]. Gastroenterol Clin Biol 1996; 20 (3) 263-268
    PubMedGoogle Scholar
  • 89 Foreman MG, Mannino DM, Moss M. Cirrhosis as a risk factor for sepsis and death: analysis of the National Hospital Discharge Survey. Chest 2003; 124 (3) 1016-1020
    CrossrefPubMedGoogle Scholar
  • 90 Zauner CA, Apsner RC, Kranz A , et al. Outcome prediction for patients with cirrhosis of the liver in a medical ICU: a comparison of the APACHE scores and liver-specific scoring systems. Intensive Care Med 1996; 22 (6) 559-563
    CrossrefPubMedGoogle Scholar
  • 91 Rabe C, Schmitz V, Paashaus M , et al. Does intubation really equal death in cirrhotic patients? Factors influencing outcome in patients with liver cirrhosis requiring mechanical ventilation. Intensive Care Med 2004; 30 (8) 1564-1571
    PubMedGoogle Scholar
  • 92 Amato MB, Barbas CS, Medeiros DM , et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338 (6) 347-354
    CrossrefPubMedGoogle Scholar
  • 93 The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342 (18) 1301-1308
    CrossrefPubMedGoogle Scholar
  • 94 Brochard L, Roudot-Thoraval F, Roupie E , et al. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trial Group on Tidal Volume Reduction in ARDS. Am J Respir Crit Care Med 1998; 158 (6) 1831-1838
    CrossrefPubMedGoogle Scholar
  • 95 Stewart TE, Meade MO, Cook DJ , et al; Pressure- and Volume-Limited Ventilation Strategy Group. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. N Engl J Med 1998; 338 (6) 355-361
    CrossrefPubMedGoogle Scholar
  • 96 Brower RG, Shanholtz CB, Fessler HE , et al. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999; 27 (8) 1492-1498
    CrossrefPubMedGoogle Scholar
  • 97 Idell S. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med 2003; 31 (4, Suppl) S213-S220
    CrossrefPubMedGoogle Scholar
  • 98 Gattinoni L, Mascheroni D, Torresin A , et al. Morphological response to positive end expiratory pressure in acute respiratory failure: computerized tomography study. Intensive Care Med 1986; 12 (3) 137-142
    PubMedGoogle Scholar
  • 99 Ranieri VM, Suter PM, Tortorella C , et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 1999; 282 (1) 54-61
    CrossrefPubMedGoogle Scholar
  • 100 Ranieri VM, Giunta F, Suter PM, Slutsky AS. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA 2000; 284 (1) 43-44
    CrossrefPubMedGoogle Scholar
  • 101 Headley AS, Tolley E, Meduri GU. Infections and the inflammatory response in acute respiratory distress syndrome. Chest 1997; 111 (5) 1306-1321
    CrossrefPubMedGoogle Scholar
  • 102 Roumen RM, Hendriks T, van der Ven-Jongekrijg J , et al. Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure. Ann Surg 1993; 218 (6) 769-776
    CrossrefPubMedGoogle Scholar
  • 103 Stüber F, Wrigge H, Schroeder S , et al. Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Med 2002; 28 (7) 834-841
    CrossrefPubMedGoogle Scholar
  • 104 Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 1998; 157 (1) 294-323
    CrossrefPubMedGoogle Scholar
  • 105 Brower RG, Lanken PN, MacIntyre N , et al; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004; 351 (4) 327-336
    CrossrefPubMedGoogle Scholar
  • 106 Rodríguez-Roisin R, Krowka MJ, Hervé P, Fallon MB ; ERS Task Force Pulmonary-Hepatic Vascular Disorders (PHD) Scientific Committee. Pulmonary-hepatic vascular disorders (PHD). Eur Respir J 2004; 24 (5) 861-880
    CrossrefPubMedGoogle Scholar
  • 107 Funk GC, Doberer D, Kneidinger N, Lindner G, Holzinger U, Schneeweiss B. Acid-base disturbances in critically ill patients with cirrhosis. Liver Int 2007; 27 (7) 901-909
    CrossrefPubMedGoogle Scholar
  • 108 Pinsky MR. The hemodynamic consequences of mechanical ventilation: an evolving story. Intensive Care Med 1997; 23 (5) 493-503
    CrossrefPubMedGoogle Scholar
  • 109 Brienza N, Revelly JP, Ayuse T, Robotham JL. Effects of PEEP on liver arterial and venous blood flows. Am J Respir Crit Care Med 1995; 152 (2) 504-510
    PubMedGoogle Scholar
  • 110 Winsö O, Biber B, Gustavsson B, Holm C, Milsom I, Niemand D. Portal blood flow in man during graded positive end-expiratory pressure ventilation. Intensive Care Med 1986; 12 (2) 80-85
    PubMedGoogle Scholar
  • 111 Matuschak GM, Pinsky MR, Rogers RM. Effects of positive end-expiratory pressure on hepatic blood flow and performance. J Appl Physiol 1987; 62 (4) 1377-1383
    PubMedGoogle Scholar
  • 112 Varpula T, Valta P, Niemi R, Takkunen O, Hynynen M, Pettilä VV. Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome. Acta Anaesthesiol Scand 2004; 48 (6) 722-731
    CrossrefPubMedGoogle Scholar
  • 113 Bollen CW, van Well GT, Sherry T , et al. High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]. Crit Care 2005; 9 (4) R430-R439
    CrossrefPubMedGoogle Scholar
  • 114 Sun HY, Cacciarelli TV, Singh N. Impact of pretransplant infections on clinical outcomes of liver transplant recipients. Liver Transpl 2010; 16 (2) 222-228
    CrossrefPubMedGoogle Scholar
  • 115 Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 2007; 334 (7597) 779
    CrossrefPubMedGoogle Scholar
  • 116 Burns KE, Adhikari NK, Keenan SP, Meade M. Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ 2009; 338: b1574
    CrossrefPubMedGoogle Scholar
  • 117 Antonelli M, Conti G, Bufi M , et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA 2000; 283 (2) 235-241
    CrossrefPubMedGoogle Scholar
  • 118 Hilbert G, Gruson D, Vargas F , et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001; 344 (7) 481-487
    CrossrefPubMedGoogle Scholar
  • 119 Narita M, Hatano E, Nagata H , et al. Prophylactic respiratory management after liver resection with bilevel positive airway pressure ventilation: report of three cases. Surg Today 2009; 39 (2) 172-174
    CrossrefPubMedGoogle Scholar
  • 120 Nagai S, Fujimoto Y, Kamei H, Nakamura T, Kiuchi T. Noninvasive positive pressure ventilation to prevent respiratory collapse after extubation: clinical case reports. Transplant Proc 2009; 41 (9) 3919-3922
    CrossrefPubMedGoogle Scholar
  • 121 Gunnarsson L, Tokics L, Gustavsson H, Hedenstierna G. Influence of age on atelectasis formation and gas exchange impairment during general anaesthesia. Br J Anaesth 1991; 66 (4) 423-432
    CrossrefPubMedGoogle Scholar
  • 122 Hedenstierna G, Tokics L, Strandberg A, Lundquist H, Brismar B. Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Acta Anaesthesiol Scand 1986; 30 (2) 183-191
    CrossrefPubMedGoogle Scholar
  • 123 Jensen AG, Kalman SH, Eintrei C, Fransson SG, Morales O. Atelectasis and oxygenation in major surgery with either propofol with or without nitrous oxide or isoflurane anaesthesia. Anaesthesia 1993; 48 (12) 1094-1096
    PubMedGoogle Scholar
  • 124 Rothen HU, Sporre B, Engberg G, Wegenius G, Högman M, Hedenstierna G. Influence of gas composition on recurrence of atelectasis after a reexpansion maneuver during general anesthesia. Anesthesiology 1995; 82 (4) 832-842
    CrossrefPubMedGoogle Scholar
  • 125 Tenling A, Hachenberg T, Tydén H, Wegenius G, Hedenstierna G. Atelectasis and gas exchange after cardiac surgery. Anesthesiology 1998; 89 (2) 371-378
    CrossrefPubMedGoogle Scholar
  • 126 Tusman G, Böhm SH, Tempra A , et al. Effects of recruitment maneuver on atelectasis in anesthetized children. Anesthesiology 2003; 98 (1) 14-22
    CrossrefPubMedGoogle Scholar
  • 127 Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 1970; 28 (5) 596-608
    PubMedGoogle Scholar
  • 128 Seeger W, Günther A, Walmrath HD, Grimminger F, Lasch HG. Alveolar surfactant and adult respiratory distress syndrome: pathogenetic role and therapeutic prospects. Clin Investig 1993; 71 (3) 177-190
    PubMedGoogle Scholar
  • 129 Pinhu L, Whitehead T, Evans T, Griffiths M. Ventilator-associated lung injury. Lancet 2003; 361 (9354) 332-340
    CrossrefPubMedGoogle Scholar
  • 130 Verbrugge SJC, Lachmann B. Surfactant replacement therapy in experimental and clinical studies. Appl Cardiopulm Pathophysiol 1998; 7: 237-250
    PubMedGoogle Scholar
  • 131 Hartog A, Gommers D, Verbrugge SJ , et al. Maintaining high lung volume during surfactant depletion attenuates the decrease in lung function. Intensive Care Med 1997; 23: S13
    PubMedGoogle Scholar
  • 132 Hartog A, Vazquez de Anda GF, Gommers D, Kaisers U, Lachmann B. At surfactant deficiency, application of “the open lung concept” prevents protein leakage and attenuates changes in lung mechanics. Crit Care Med 2000; 28 (5) 1450-1454
    CrossrefPubMedGoogle Scholar
  • 133 Lachmann B, Danzmann E, Haendly B , et al. Ventilator settings and gas exchange in respiratory distress syndrome. In: Prakash O, , ed. Applied Physiology in Clinical Respiratory Care. The Hague: Martinus Nijhoff; 1982: 141-176
    Google Scholar
  • 134 Papadakos PJ, Lachmann B. The open lung concept of alveolar recruitment can improve outcome in respiratory failure and ARDS. Mt Sinai J Med 2002; 69 (1-2) 73-77
    PubMedGoogle Scholar
  • 135 Halter JM, Steinberg JM, Schiller HJ , et al. Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med 2003; 167 (12) 1620-1626
    CrossrefPubMedGoogle Scholar
  • 136 Schreiter D, Reske A, Scheibner L, Glien C, Katscher S, Josten C. The open lung concept: clinical application in severe thoracic trauma [in German]. Chirurg 2002; 73 (4) 353-359
    CrossrefPubMedGoogle Scholar
  • 137 van Kaam AH, de Jaegere A, Haitsma JJ, Van Aalderen WM, Kok JH, Lachmann B. Positive pressure ventilation with the open lung concept optimizes gas exchange and reduces ventilator-induced lung injury in newborn piglets. Pediatr Res 2003; 53 (2) 245-253
    CrossrefPubMedGoogle Scholar
  • 138 Reis Miranda D, Struijs A, Koetsier P , et al. Open lung ventilation improves functional residual capacity after extubation in cardiac surgery. Crit Care Med 2005; 33 (10) 2253-2258
    CrossrefPubMedGoogle Scholar
  • 139 Haitsma JJ, Uhlig S, Göggel R, Verbrugge SJ, Lachmann U, Lachmann B. Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-alpha. Intensive Care Med 2000; 26 (10) 1515-1522
    CrossrefPubMedGoogle Scholar
  • 140 Verbrugge SJ, Sorm V, van ’t Veen A, Mouton JW, Gommers D, Lachmann B. Lung overinflation without positive end-expiratory pressure promotes bacteremia after experimental Klebsiella pneumoniae inoculation. Intensive Care Med 1998; 24 (2) 172-177
    CrossrefPubMedGoogle Scholar
  • 141 Rouby JJ, Constantin JM, Roberto De A Girardi C, Zhang M, Lu Q. Mechanical ventilation in patients with acute respiratory distress syndrome. Anesthesiology 2004; 101 (1) 228-234
    CrossrefPubMedGoogle Scholar
  • 142 Abelmann WH, Frank NR, Gaensler EA, Cugell DW. Effects of abdominal distention by ascites on lung volumes and ventilation. AMA Arch Intern Med 1954; 93 (4) 528-540
    CrossrefPubMedGoogle Scholar
  • 143 Angueira CE, Kadakia SC. Effects of large-volume paracentesis on pulmonary function in patients with tense cirrhotic ascites. Hepatology 1994; 20 (4 Pt 1) 825-828
    PubMedGoogle Scholar
  • 144 Byrd Jr RP, Roy TM, Simons M. Improvement in oxygenation after large volume paracentesis. South Med J 1996; 89 (7) 689-692
    CrossrefPubMedGoogle Scholar
  • 145 Gupta D, Lalrothuama Agrawal PN , et al. Pulmonary function changes after large volume paracentesis. Trop Gastroenterol 2000; 21 (2) 68-70
    PubMedGoogle Scholar
  • 146 Chao Y, Wang SS, Lee SD, Shiao GM, Chang HI, Chang SC. Effect of large-volume paracentesis on pulmonary function in patients with cirrhosis and tense ascites. J Hepatol 1994; 20 (1) 101-105
    PubMedGoogle Scholar
  • 147 Duranti R, Laffi G, Misuri G , et al. Respiratory mechanics in patients with tense cirrhotic ascites. Eur Respir J 1997; 10 (7) 1622-1630
    CrossrefPubMedGoogle Scholar
  • 148 Haitsma JJ, Lachmann RA, Lachmann B. Open lung in ARDS. Acta Pharmacol Sin 2003; 24 (12) 1304-1307
    PubMedGoogle Scholar
  • 149 Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342 (18) 1334-1349
    CrossrefPubMedGoogle Scholar
  • 150 Grasso S, Mascia L, Del Turco M , et al. Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy. Anesthesiology 2002; 96 (4) 795-802
    CrossrefPubMedGoogle Scholar
  • 151 Constantin JM, Grasso S, Chanques G , et al. Lung morphology predicts response to recruitment maneuver in patients with acute respiratory distress syndrome. Crit Care Med 2010; 38 (4) 1108-1117
    CrossrefPubMedGoogle Scholar
  • 152 Brochard L, Roudot-Thoraval F, Roupie E , et al. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trial Group on Tidal Volume Reduction in ARDS. Am J Respir Crit Care Med 1998; 158 (6) 1831-1838
    CrossrefPubMedGoogle Scholar
  • 153 Larsen FS, Hansen BA, Blei AT. Intensive care management of patients with acute liver failure with emphasis on systemic hemodynamic instability and cerebral edema: a critical appraisal of pathophysiology. Can J Gastroenterol 2000; 14 (Suppl 0D) 105D-111D
    PubMedGoogle Scholar
  • 154 Kramer DJ, Aggarwal S, Martin M , et al. Management options in fulminant hepatic failure. Transplant Proc 1991; 23 (3) 1895-1898
    PubMedGoogle Scholar
  • 155 Stravitz RT, Kramer DJ. Management of acute liver failure. Nat Rev Gastroenterol Hepatol 2009; 6 (9) 542-553
    CrossrefPubMedGoogle Scholar
  • 156 Bonnet F, Richard C, Glaser P, Lafay M, Guesde R. Changes in hepatic flow induced by continuous positive pressure ventilation in critically ill patients. Crit Care Med 1982; 10 (11) 703-705
    CrossrefPubMedGoogle Scholar
  • 157 Wendon JA, Harrison PM, Keays R, Williams R. Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 1994; 19 (6) 1407-1413
    CrossrefPubMedGoogle Scholar
  • 158 Strauss GI, Høgh P, Møller K, Knudsen GM, Hansen BA, Larsen FS. Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology 1999; 30 (6) 1368-1373
    CrossrefPubMedGoogle Scholar
  • 159 Strauss G, Hansen BA, Knudsen GM, Larsen FS. Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure. J Hepatol 1998; 28 (2) 199-203
    PubMedGoogle Scholar
  • 160 Kennedy TC, Knudson RJ. Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis. Chest 1977; 72 (3) 305-309
    CrossrefPubMedGoogle Scholar
  • 161 Fluckiger M. Vorkommen von trommelschlägelförmigen Fingerendphalangen ohne chronische Veränderungen an der Lungen oder am Herzen. Wien Med Wochenschr 1884; 34: 1457
    PubMedGoogle Scholar
  • 162 Hoeper MM, Krowka MJ, Strassburg CP. Portopulmonary hypertension and hepatopulmonary syndrome. Lancet 2004; 363 (9419) 1461-1468
    CrossrefPubMedGoogle Scholar
  • 163 Krowka MJ, Cortese DA. Hepatopulmonary syndrome: current concepts in diagnostic and therapeutic considerations. Chest 1994; 105 (5) 1528-1537
    CrossrefPubMedGoogle Scholar
  • 164 Colle I, Van Steenkiste C, Geerts A, Van Vlierberghe H. Hepatopulmonary syndrome and portopulmonary hypertension: what's new?. Acta Gastroenterol Belg 2007; 70 (2) 203-209
    PubMedGoogle Scholar
  • 165 Rodríguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome—a liver-induced lung vascular disorder. N Engl J Med 2008; 358 (22) 2378-2387
    CrossrefPubMedGoogle Scholar
  • 166 Krowka MJ, Cortese DA. Pulmonary aspects of liver disease and liver transplantation. Clin Chest Med 1989; 10 (4) 593-616
    PubMedGoogle Scholar
  • 167 Lange PA, Stoller JK. The hepatopulmonary syndrome. Ann Intern Med 1995; 122 (7) 521-529
    CrossrefPubMedGoogle Scholar
  • 168 Schenk P, Schöniger-Hekele M, Fuhrmann V, Madl C, Silberhumer G, Müller C. Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis. Gastroenterology 2003; 125 (4) 1042-1052
    CrossrefPubMedGoogle Scholar
  • 169 Krowka MJ, Tajik AJ, Dickson ER, Wiesner RH, Cortese DA. Intrapulmonary vascular dilatations (IPVD) in liver transplant candidates: screening by two-dimensional contrast-enhanced echocardiography. Chest 1990; 97 (5) 1165-1170
    CrossrefPubMedGoogle Scholar
  • 170 Stoller JK, Lange PA, Westveer MK, Carey WD, Vogt D, Henderson JM. Prevalence and reversibility of the hepatopulmonary syndrome after liver transplantation. The Cleveland Clinic experience. West J Med 1995; 163 (2) 133-138
    PubMedGoogle Scholar
  • 171 Hopkins WE, Waggoner AD, Barzilai B. Frequency and significance of intrapulmonary right-to-left shunting in end-stage hepatic disease. Am J Cardiol 1992; 70 (4) 516-519
    CrossrefPubMedGoogle Scholar
  • 172 Arguedas MR, Singh H, Faulk DK, Fallon MB. Utility of pulse oximetry screening for hepatopulmonary syndrome. Clin Gastroenterol Hepatol 2007; 5 (6) 749-754
    CrossrefPubMedGoogle Scholar
  • 173 Berthelot P, Walker JG, Sherlock S, Reid L. Arterial changes in the lungs in cirrhosis of the liver—lung spider nevi. N Engl J Med 1966; 274 (6) 291-298
    CrossrefPubMedGoogle Scholar
  • 174 Agusti AGN, Roca J, Rodriguez-Roisin R, Mastai R, Wagner PD, Bosch J. Pulmonary hemodynamics and gas exchange during exercise in liver cirrhosis. Am Rev Respir Dis 1989; 139 (2) 485-491
    CrossrefPubMedGoogle Scholar
  • 175 Krowka MJ, Dickson ER, Cortese DA. Hepatopulmonary syndrome: clinical observations and lack of therapeutic response to somatostatin analogue. Chest 1993; 104 (2) 515-521
    CrossrefPubMedGoogle Scholar
  • 176 Krowka MJ. Clinical management of hepatopulmonary syndrome. Semin Liver Dis 1993; 13 (4) 414-422
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 177 Rolla G, Brussino L, Colagrande P , et al. Exhaled nitric oxide and oxygenation abnormalities in hepatic cirrhosis. Hepatology 1997; 26 (4) 842-847
    CrossrefPubMedGoogle Scholar
  • 178 Vachiéry F, Moreau R, Hadengue A , et al. Hypoxemia in patients with cirrhosis: relationship with liver failure and hemodynamic alterations. J Hepatol 1997; 27 (3) 492-495
    CrossrefPubMedGoogle Scholar
  • 179 Krowka MJ, Wiseman GA, Burnett OL , et al. Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO(2) response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning. Chest 2000; 118 (3) 615-624
    CrossrefPubMedGoogle Scholar
  • 180 Whyte MK, Hughes JM, Peters AM, Ussov W, Patel S, Burroughs AK. Analysis of intrapulmonary right to left shunt in the hepatopulmonary syndrome. J Hepatol 1998; 29 (1) 85-93
    CrossrefPubMedGoogle Scholar
  • 181 Fallon MB, Abrams GA. Pulmonary dysfunction in chronic liver disease. Hepatology 2000; 32 (4 Pt 1) 859-865
    CrossrefPubMedGoogle Scholar
  • 182 Battaglia SE, Pretto JJ, Irving LB, Jones RM, Angus PW. Resolution of gas exchange abnormalities and intrapulmonary shunting following liver transplantation. Hepatology 1997; 25 (5) 1228-1232
    CrossrefPubMedGoogle Scholar
  • 183 Stoller JK, Moodie D, Schiavone WA , et al. Reduction of intrapulmonary shunt and resolution of digital clubbing associated with primary biliary cirrhosis after liver transplantation. Hepatology 1990; 11 (1) 54-58
    CrossrefPubMedGoogle Scholar
  • 184 Swanson KL, Wiesner RH, Krowka MJ. Natural history of hepatopulmonary syndrome: impact of liver transplantation. Hepatology 2005; 41 (5) 1122-1129
    CrossrefPubMedGoogle Scholar
  • 185 Collisson EA, Nourmand H, Fraiman MH , et al. Retrospective analysis of the results of liver transplantation for adults with severe hepatopulmonary syndrome. Liver Transpl 2002; 8 (10) 925-931
    CrossrefPubMedGoogle Scholar
  • 186 Taillé C, Cadranel J, Bellocq A , et al. Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France. Transplantation 2003; 75 (9) 1482-1489 , discussion 1446–1447
    CrossrefPubMedGoogle Scholar
  • 187 Arguedas MR, Abrams GA, Krowka MJ, Fallon MB. Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation. Hepatology 2003; 37 (1) 192-197
    CrossrefPubMedGoogle Scholar
  • 188 Fallon MB. Hepatopulmonary syndrome: more than just a matter of tone?. Hepatology 2006; 43 (5) 912-914
    CrossrefPubMedGoogle Scholar
  • 189 Mantz Jr FA, Craige E. Portal axis thrombosis with spontaneous portacaval shunt and resultant cor pulmonale. AMA Arch Pathol 1951; 52 (1) 91-97
    PubMedGoogle Scholar
  • 190 Badesch DB, Champion HC, Sanchez MA , et al. Diagnosis and assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2009; 54 (1, Suppl) S55-S66
    CrossrefPubMedGoogle Scholar
  • 191 Hoeper MM. Definition, classification, and epidemiology of pulmonary arterial hypertension. Semin Respir Crit Care Med 2009; 30 (4) 369-375
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 192 Lebrec D, Capron JP, Dhumeaux D, Benhamou JP. Pulmonary hypertension complicating portal hypertension. Am Rev Respir Dis 1979; 120 (4) 849-856
    PubMedGoogle Scholar
  • 193 Mandell MS, Groves BM. Pulmonary hypertension in chronic liver disease. Clin Chest Med 1996; 17 (1) 17-33
    CrossrefPubMedGoogle Scholar
  • 194 Panos RJ, Baker SK. Mediators, cytokines, and growth factors in liver-lung interactions. Clin Chest Med 1996; 17 (1) 151-169
    CrossrefPubMedGoogle Scholar
  • 195 Egermayer P, Town GI, Peacock AJ. Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension. Thorax 1999; 54 (2) 161-168
    CrossrefPubMedGoogle Scholar
  • 196 Maruyama T, Ohsaki K, Shimoda S, Kaji Y, Harada M. Thromboxane-dependent portopulmonary hypertension. Am J Med 2005; 118 (1) 93-94
    PubMedGoogle Scholar
  • 197 Nichols WC, Koller DL, Slovis B , et al. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat Genet 1997; 15 (3) 277-280
    CrossrefPubMedGoogle Scholar
  • 198 Deng Z, Haghighi F, Helleby L , et al. Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3-cM region on chromosome 2q33. Am J Respir Crit Care Med 2000; 161 (3 Pt 1) 1055-1059
    CrossrefPubMedGoogle Scholar
  • 199 Deng Z, Morse JH, Slager SL , et al. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 2000; 67 (3) 737-744
    CrossrefPubMedGoogle Scholar
  • 200 Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 2000; 275 (23) 17647-17652
    CrossrefPubMedGoogle Scholar
  • 201 Kawut SM, Krowka MJ, Trotter JF , et al; Pulmonary Vascular Complications of Liver Disease Study Group. Clinical risk factors for portopulmonary hypertension. Hepatology 2008; 48 (1) 196-203
    CrossrefPubMedGoogle Scholar
  • 202 Edwards BS, Weir EK, Edwards WD, Ludwig J, Dykoski RK, Edwards JE. Coexistent pulmonary and portal hypertension: morphologic and clinical features. J Am Coll Cardiol 1987; 10 (6) 1233-1238
    CrossrefPubMedGoogle Scholar
  • 203 Schraufnagel DE, Kay JM. Structural and pathologic changes in the lung vasculature in chronic liver disease. Clin Chest Med 1996; 17 (1) 1-15
    CrossrefPubMedGoogle Scholar
  • 204 Robalino BD, Moodie DS. Association between primary pulmonary hypertension and portal hypertension: analysis of its pathophysiology and clinical, laboratory and hemodynamic manifestations. J Am Coll Cardiol 1991; 17 (2) 492-498
    CrossrefPubMedGoogle Scholar
  • 205 Krowka MJ, Swanson KL, Frantz RP, McGoon MD, Wiesner RH. Portopulmonary hypertension: results from a 10-year screening algorithm. Hepatology 2006; 44 (6) 1502-1510
    CrossrefPubMedGoogle Scholar
  • 206 Colle IO, Moreau R, Godinho E , et al. Diagnosis of portopulmonary hypertension in candidates for liver transplantation: a prospective study. Hepatology 2003; 37 (2) 401-409
    CrossrefPubMedGoogle Scholar
  • 207 Murray KF, Carithers Jr RL ; AASLD. AASLD practice guidelines: evaluation of the patient for liver transplantation. Hepatology 2005; 41 (6) 1407-1432
    CrossrefPubMedGoogle Scholar
  • 208 Krowka MJ. Portopulmonary hypertension: diagnostic advances and caveats. Liver Transpl 2003; 9 (12) 1336-1337
    PubMedGoogle Scholar
  • 209 Hoeper MM, Rubin LJ. Update in pulmonary hypertension 2005. Am J Respir Crit Care Med 2006; 173 (5) 499-505
    CrossrefPubMedGoogle Scholar
  • 210 McLaughlin VV, McGoon MD. Pulmonary arterial hypertension. Circulation 2006; 114 (13) 1417-1431
    CrossrefPubMedGoogle Scholar
  • 211 Rubin LJ. Primary pulmonary hypertension. N Engl J Med 1997; 336 (2) 111-117
    CrossrefPubMedGoogle Scholar
  • 212 Rich S. The medical treatment of primary pulmonary hypertension. Proven and promising strategies. Chest 1994; 105 (2, Suppl) 17S-20S
    CrossrefPubMedGoogle Scholar
  • 213 Friedman R, Mears JG, Barst RJ. Continuous infusion of prostacyclin normalizes plasma markers of endothelial cell injury and platelet aggregation in primary pulmonary hypertension. Circulation 1997; 96 (9) 2782-2784
    CrossrefPubMedGoogle Scholar
  • 214 Wells JT, Runo JR, Lucey MR. Portopulmonary hypertension. Hepatology 2008; 48 (1) 13-15
    CrossrefPubMedGoogle Scholar
  • 215 Tan HP, Markowitz JS, Montgomery RA , et al. Liver transplantation in patients with severe portopulmonary hypertension treated with preoperative chronic intravenous epoprostenol. Liver Transpl 2001; 7 (8) 745-749
    CrossrefPubMedGoogle Scholar
  • 216 Kett DH, Acosta RC, Campos MA, Rodriguez MJ, Quartin AA, Schein RM. Recurrent portopulmonary hypertension after liver transplantation: management with epoprostenol and resolution after retransplantation. Liver Transpl 2001; 7 (7) 645-648
    CrossrefPubMedGoogle Scholar
  • 217 Koneru B, Ahmed S, Weisse AB, Grant GP, McKim KA. Resolution of pulmonary hypertension of cirrhosis after liver transplantation. Transplantation 1994; 58 (10) 1133-1135
    PubMedGoogle Scholar
  • 218 De Wolf AM, Scott VL, Gasior T, Kang Y. Pulmonary hypertension and liver transplantation. Anesthesiology 1993; 78 (1) 213-214
    PubMedGoogle Scholar
  • 219 Schott R, Chaouat A, Launoy A, Pottecher T, Weitzenblum E. Improvement of pulmonary hypertension after liver transplantation. Chest 1999; 115 (6) 1748-1749
    CrossrefPubMedGoogle Scholar
  • 220 Kawut SM, Taichman DB, Ahya VN , et al. Hemodynamics and survival of patients with portopulmonary hypertension. Liver Transpl 2005; 11 (9) 1107-1111
    CrossrefPubMedGoogle Scholar
  • 221 Cardenas A, Kelleher T, Chopra S. Review article: hepatic hydrothorax. Aliment Pharmacol Ther 2004; 20 (3) 271-279
    CrossrefPubMedGoogle Scholar
  • 222 Strauss RM, Boyer TD. Hepatic hydrothorax. Semin Liver Dis 1997; 17 (3) 227-232
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 223 Xiol X, Guardiola J. Hepatic hydrothorax. Curr Opin Pulm Med 1998; 4 (4) 239-242
    CrossrefPubMedGoogle Scholar
  • 224 Kinasewitz GT, Keddissi JI. Hepatic hydrothorax. Curr Opin Pulm Med 2003; 9 (4) 261-265
    CrossrefPubMedGoogle Scholar
  • 225 Huang PM, Chang YL, Yang CY, Lee YC. The morphology of diaphragmatic defects in hepatic hydrothorax: thoracoscopic finding. J Thorac Cardiovasc Surg 2005; 130 (1) 141-145
    CrossrefPubMedGoogle Scholar
  • 226 Mouroux J, Perrin C, Venissac N, Blaive B, Richelme H. Management of pleural effusion of cirrhotic origin. Chest 1996; 109 (4) 1093-1096
    CrossrefPubMedGoogle Scholar
  • 227 Zenda T, Miyamoto S, Murata S, Mabuchi H. Detection of diaphragmatic defect as the cause of severe hepatic hydrothorax with magnetic resonance imaging. Am J Gastroenterol 1998; 93 (11) 2288-2289
    CrossrefPubMedGoogle Scholar
  • 228 Cárdenas A, Arroyo V. Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites. Best Pract Res Clin Endocrinol Metab 2003; 17 (4) 607-622
    CrossrefPubMedGoogle Scholar
  • 229 Lazaridis KN, Frank JW, Krowka MJ, Kamath PS. Hepatic hydrothorax: pathogenesis, diagnosis, and management. Am J Med 1999; 107 (3) 262-267
    CrossrefPubMedGoogle Scholar
  • 230 Serrat J, Roza JJ, Planella T. Hepatic hydrothorax in the absence of ascites: respiratory failure in a cirrhotic patient. Anesth Analg 2004; 99 (6) 1803-1804
    PubMedGoogle Scholar
  • 231 Alagiakrishnan K, Patel PJ. Left-sided hepatic hydrothorax with ascites. Int J Clin Pract 1999; 53 (3) 225-226
    PubMedGoogle Scholar
  • 232 Xiol X, Castellote J, Cortes-Beut R, Delgado M, Guardiola J, Sesé E. Usefulness and complications of thoracentesis in cirrhotic patients. Am J Med 2001; 111 (1) 67-69
    CrossrefPubMedGoogle Scholar
  • 233 Xiol X, Castellví JM, Guardiola J , et al. Spontaneous bacterial empyema in cirrhotic patients: a prospective study. Hepatology 1996; 23 (4) 719-723
    CrossrefPubMedGoogle Scholar
  • 234 Xiol X, Tremosa G, Castellote J , et al. Liver transplantation in patients with hepatic hydrothorax. Transpl Int 2005; 18 (6) 672-675
    CrossrefPubMedGoogle Scholar
  • 235 Strauss RM, Martin LG, Kaufman SL, Boyer TD. Transjugular intrahepatic portal systemic shunt for the management of symptomatic cirrhotic hydrothorax. Am J Gastroenterol 1994; 89 (9) 1520-1522
    PubMedGoogle Scholar
  • 236 Siegerstetter V, Deibert P, Ochs A, Olschewski M, Blum HE, Rössle M. Treatment of refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt: long-term results in 40 patients. Eur J Gastroenterol Hepatol 2001; 13 (5) 529-534
    CrossrefPubMedGoogle Scholar
  • 237 Spencer EB, Cohen DT, Darcy MD. Safety and efficacy of transjugular intrahepatic portosystemic shunt creation for the treatment of hepatic hydrothorax. J Vasc Interv Radiol 2002; 13 (4) 385-390
    CrossrefPubMedGoogle Scholar
  • 238 Conklin LD, Estrera AL, Weiner MA, Reardon PR, Reardon MJ. Transjugular intrahepatic portosystemic shunt for recurrent hepatic hydrothorax. Ann Thorac Surg 2000; 69 (2) 609-611
    CrossrefPubMedGoogle Scholar
  • 239 Rössle M, Gerbes AL. TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. Gut 2010; 59 (7) 988-1000
    CrossrefPubMedGoogle Scholar
  • 240 Dhanasekaran R, West JK, Gonzales PC , et al. Transjugular intrahepatic portosystemic shunt for symptomatic refractory hepatic hydrothorax in patients with cirrhosis. Am J Gastroenterol 2010; 105 (3) 635-641
    CrossrefPubMedGoogle Scholar
  • 241 Borchardt J, Smirnov A, Metchnik L, Malnick S. Treating hepatic hydrothorax. BMJ 2003; 326 (7392) 751-752
    PubMedGoogle Scholar
  • 242 Runyon BA, Greenblatt M, Ming RH. Hepatic hydrothorax is a relative contraindication to chest tube insertion. Am J Gastroenterol 1986; 81 (7) 566-567
    PubMedGoogle Scholar
  • 243 Liu LU, Haddadin HA, Bodian CA , et al. Outcome analysis of cirrhotic patients undergoing chest tube placement. Chest 2004; 126 (1) 142-148
    CrossrefPubMedGoogle Scholar