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Deutsche Zeitschrift für Onkologie 2012; 44(1): 17-25
DOI: 10.1055/s-0031-1298687
Forschung
© Karl F. Haug Verlag MVS Medizinverlage Stuttgart GmbH & Co. KG

Prognose beim Mammakarzinom

Martina Vetter
,
Eva Johanna Kantelhardt
,
Christoph Thomssen
Further Information

Publication History

Publication Date:
28 March 2012 (online)

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Zusammenfassung

Die Nutzung von Prognosefaktoren zur adjuvanten Therapieentscheidung ist Standard bei Patientinnen mit neu diagnostiziertem Mammakarzinom. In der folgenden Übersicht werden etablierte und innovative Biomarker vorgestellt. Biologische Grundlage, Testverfahren und Bewertung durch aktuelle evidenzbasierte Leitlinien werden kritisch diskutiert. Ziel der modernen Medizin ist die individuelle Therapie der Patientin unter Vermeidung von Unter- oder Übertherapie.

Summary

The use of prognostic factors to decide on adjuvant therapy in patients with newly diagnosed breast cancer is state of the art. This short review presents established and innovative biomarkers. Basic biologic mechanisms, nature of the test as well as rating within current clinical guidelines are discussed critically. The aim is tailored therapy for the individual patient avoiding over- and undertherapie.

Schlüsselwörter

Prognose - Prädiktion - innovative Biomarker - adjuvante Therapie - Mammakarzinom

Keywords

Adjuvant chemotherapy - breast cancer - prognosis prediction - biological marker
 

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