Risk factors for degenerative spondylolisthesis: a systematic review

ABSTRACT

Study design: Systematic literature review.

Rationale: Many authors have postulated on various risk factors associated with the pathogenesis of degenerative spondylolisthesis (DS), yet controversies regarding those risk factors still exist.

Objective: To critically appraise and summarize evidence on risk factors for DS.

Methods: Articles published before October 15, 2011, were systematically reviewed using PubMed and bibliographies of key articles. Each article was subject to quality rating and was analyzed by two independent reviewers.

Results: From 382 citations, 30 underwent full-text review. Fourteen studies met inclusion criteria. All but two were considered poor quality. Female gender and higher facet joint angle were consistently associated with an increased risk of DS across multiple studies. Multiple studies also consistently reported no association between back pain and prolonged occupational sitting. Associations between age, parity, lumbosacral angle, lumbar lordosis, facet joint tropism, and pelvic inclination angles were inconsistent.

Conclusions: There appears to be consistent evidence to suggest that the risk of DS increases with increasing age and is greater for females and people with a greater facet joint angle.

• REFERENCES

• 1 Junghanns H. 1930; Spondylolisthesis ohne spalt in zwischengelenstuck. Arch Orthop Unfallchir 29: 118-127 German.
• 2 Mariconda M, Galasso O, Imbimbo L et al. 2007; Relationship between alterations of the lumbar spine, visualized with magnetic resonance imaging, and occupational variables. Eur Spine J 16 (2) 255-266
• 3 Jacobsen S, Sonne-Holm S, Rovsing H et al. 2007; Degenerative lumbar spondylolisthesis: an epidemiological perspective: the Copenhagen Osteoarthritis Study. Spine (Phila Pa 1976) 32 (1) 120-125
• 4 Hosoe H, Ohmori K. 2008; Degenerative lumbosacral spondylolisthesis: possible factors which predispose the fifth lumbar vertebra to slip. J Bone Joint Surg Br 90 (3) 356-359
• 5 Horikawa K, Kasai Y, Yamakawa T et al. 2006; Prevalence of osteoarthritis, osteoporotic vertebral fractures, and spondylolisthesis among the elderly in a Japanese village. J Orthop Surg (Hong Kong) 14 (1) 9-12
• 6 Sanderson PL, Fraser RD. 1996; The influence of pregnancy on the development of degenerative spondylolisthesis. J Bone Joint Surg Br 78 (6) 951-954
• 7 Boden SD, Riew KD, Yamaguchi K et al. 1996; Orientation of the lumbar facet joints: association with degenerative disc disease. J Bone Joint Surg Am 78 (3) 403-411
• 8 Cinotti G, Postacchini F, Fassari F et al. 1997; Predisposing factors in degenerative spondylolisthesis: a radiographic and CT study. Int Orthop 21 (5) 337-342
• 9 Dai F, Belfer I, Schwartz CE et al. 2010; Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. Spine J 10 (11) 949-957
• 10 Berlemann U, Jeszenszky DJ, Buhler DW et al. 1999; The role of lumbar lordosis, vertebral end-plate inclination, disc height, and facet orientation in degenerative spondylolisthesis. J Spinal Disord 12 (1) 68-73
• 11 Grobler LJ, Robertson PA, Novotny JE et al. 1993; Etiology of spondylolisthesis: assessment of the role played by lumbar facet joint morphology. Spine (Phila Pa 1976) 18 (1) 80-91
• 12 Imada K, Matsui H, Tsuji H. 1995; Oophorectomy predisposes to degenerative spondylolisthesis. J Bone Joint Surg Br 77 (1) 126-130
• 13 Chen IR, Wei TS. 2009; Disc height and lumbar index as independent predictors of degenerative spondylolisthesis in middle-aged women with low back pain. Spine (Phila Pa 1976) 34 (13) 1402-1409
• 14 Love TW, Fagan AB, Fraser RD. 1999; Degenerative spondylolisthesis: developmental or acquired?. J Bone Joint Surg Br 81 (4) 670-674
• 15 Dai LY. 2001; Orientation and tropism of lumbar facet joints in degenerative spondylolisthesis. Int Orthop 25 (1) 40-42
• 16 Sato K, Wakamatsu E, Yoshizumi A et al. 1989; The configuration of the laminas and facet joints in degenerative spondylolisthesis: a clinicoradiologic study. Spine (Phila Pa 1976) 14 (11) 1265-1271
• 17 Wright JG, Swiontkowski MF, Heckman JD. 2003; Introducing levels of evidence to the journal. J Bone Joint Surg Am 85-A (1) 1-3
• 18 Atkins D, Best D, Briss PA et al. 2004; Grading quality of evidence and strength of recommendations. BMJ 328 (7454) 1490
• 19 West S, King V, Carey TS et al. 2002. Systems to Rate the Strength of Scientific Evidence. Evidence Report/Technology Assessment No. 47 (Prepared by the Research Triangle Institute-University of North Carolina Evidence-based Practice Center, Contract No. 290-97-0011). Rockville, MD: US Agency for Healthcare Research and Quality;