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Zeitschrift für Orthomolekulare Medizin 2012; 10(1): 20-23
DOI: 10.1055/s-0031-1298384
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Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Bedeutung von Mikronährstoffen und Mitochondrialer Medizin in der Reproduktionsmedizin

Michael Weber
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Publication History

Publication Date:
22 March 2012 (online)

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Zusammenfassung

Oxidativer Stress ist ein wichtiger pathogener Faktor für Sub- und Infertilität bei Männern und Frauen. Erhöhte Konzentrationen von reaktiven Sauerstoffspezies (ROS) beeinträchtigen sowohl Funktion und Lebensfähigkeit von Spermien als auch die Oogenese sowie das Zustandekommen und den Verlauf einer Schwangerschaft. Antioxidanzien, insbesondere Coenzym Q10, kommt daher eine besondere Bedeutung in der Therapie von Fertilitätsstörungen zu.

Schlüsselwörter

Fertilitätsstörungen - Spermienqualität - oxidativer Stress - reaktive Sauerstoffspezies (ROS) - Antioxidanzien - Coenzym Q10 - Oozyten - Mitochondriopathien
 

  • Literatur

  • 1 Tournaye H. Evidence-based management of male subfertility. Curr Opin Obstet Gynecol 2006; 18: 253-259
    CrossrefGoogle Scholar
  • 2 Attia AM, Al-Inany HG, Farquar C, Proctor M. Gonatrophins for idiopathic male factor male subfertility. Cochrane Database Syst Rev 2004; 4
    Google Scholar
  • 3 Tremellen K. Oxidative stress and male infertility – a clinical perspective. Hum Reprod Update 2008; 14: 243-258
    CrossrefGoogle Scholar
  • Showell MG, Brown J, Yazdani A et al. Antioxidants for male subfertility (Review). The Cochrane Collaboration, Wiley Publishers; 2011
    Google Scholar
  • 5 Sheweita S, Tilmisany A, Al-Sawaf H. Mechanisms of male infertility: Role of antioxidants. Curr Drug Metab 2005; 6: 495-501
    CrossrefGoogle Scholar
  • 6 Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am 2002; 29: 817-827
    CrossrefGoogle Scholar
  • 7 Koca Y, Ozdal OL, Celik M et al. Antioxidant activity of seminal plasma in fertile and infertile men. Arch Androl 2003; 49: 355-359
    Google Scholar
  • 8 Omu AE, Al-Azemi MK, Kehinde EO et al. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Med Princ Pract 2008; 17: 108-116
    CrossrefGoogle Scholar
  • 9 Bykova M, Athayde K, Sharma R et al. Defining the reference value of seminal reactive oxygen species in a population of infertile men and normal healthy volunteers. Fertil Steril 2007; 88 (Suppl. 01) (P-597) 305
    CrossrefGoogle Scholar
  • 10 Safarinejad ME. Efficacy of coenzyme Q 10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol 2009; 182: 237-248
    CrossrefGoogle Scholar
  • 11 Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3: 28
    CrossrefGoogle Scholar
  • 12 De Bruin JP, Dorland M, Spek ER et al. Ultrastructure of the resting ovarian follicle pool in healthy young women. Biol Reprod 2002; 66: 1151-1160
    CrossrefGoogle Scholar
  • 13 Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility – a clinicianʼs perspective. Reprod Biomed Online 2005; 11: 641-650
    CrossrefGoogle Scholar
  • Gvozdjáková A ed. Mitochondrial Medicine – Mitochondrial Metabolism, Diseases, Diagnosis and Therapy. Springer Netherlands; 2008
    Google Scholar
  • 15 Luck MR, Jeyaseelan I, Scholes RA. Ascorbic acid and fertility. Biol Reprod 1995; 52: 262-266
    CrossrefGoogle Scholar
  • 16 Wilding M, Dale B, Marino M et al. Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos. Hum Reprod 2001; 16: 909-917
    CrossrefGoogle Scholar
  • 17 May-Panloup P, Chrétien MF, Jacques C, Vasseur C. Low oocyte mitochondrial DNA content in ovarian insufficiency. Hum Reprod 2005; 20: 593-597
    CrossrefGoogle Scholar
  • 18 Haruna M, Matsuzaki M, Ota E et al. Positive correlation between maternal serum coenzyme Q10 levels and infant birth weight. Biofactors 2010; 36: 312-318
    CrossrefGoogle Scholar
  • 19 Teran E, Racines-Orbe M, Vivero S et al. Preeclampsia is associated with a decrease in plasma coenzyme Q10 levels. Free Radic Biol Med 2003; 35: 1453-1456
    CrossrefGoogle Scholar
  • 20 Teran E, Hernandez I, Nieto B et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet 2009; 105: 43-45
    CrossrefGoogle Scholar