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Planta Med 2012; 78(7): 720-729
DOI: 10.1055/s-0031-1298337
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Triterpene Glycosides from Astragalus angustifolius

Derya Gülcemal1 , Milena Masullo2 , Erdal Bedir3 , Michela Festa2 , Tamer Karayıldırım1 , Ozgen Alankus-Caliskan1 , Sonia Piacente2
  • 1Department of Chemistry, Faculty of Science, Ege University, Bornova, Izmir, Turkey
  • 2Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno, Fisciano, Salerno, Italy
  • 3Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, İzmir, Turkey
Further Information

Publication History

received Dec. 14, 2011 revised February 7, 2012

accepted February 13, 2012

Publication Date:
21 March 2012 (online)

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Abstract

Six new cycloartane-type (1–6) and four new oleanane-type (7–10) triterpene glycosides were isolated from Astragalus angustifolius Lam., together with five known triterpene glycosides. Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analysis. Compounds 1–3 are glycosides of cycloastragenol, while compounds 4–6 show the C-24 epimer of cycloastragenol as aglycone, encountered for the first time in nature. All compounds were evaluated for their antiproliferative activity in Hela, H-446, HT-29, and U937 cell lines. Only compound 8 displayed a weak activity with IC50 values of 36 and 50 µM against Hela and HT-29 cell lines, respectively.

Key words

Astragalus angustifolius - Leguminosae - cycloartane saponins - oleanane saponins

Supporting Information

References

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Prof. Dr. Sonia Piacente

Dipartimento di Scienze Farmaceutiche e Biomediche
Università degli Studi di Salerno

Via Ponte Don Melillo

84084 Fisciano, Salerno

Italy

Phone: +39 89 96 97 63

Fax: +39 89 96 96 02

Email: piacente@unisa.it