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Exp Clin Endocrinol Diabetes 2012; 120(03): 125-127
DOI: 10.1055/s-0031-1297993
DOI: 10.1055/s-0031-1297993
Mini-Review
Hypercortisolism Caused by Ritonavir Associated Inhibition of CYP 3A4 Under Inhalative Glucocorticoid Therapy. 2 Case Reports and a Review of the Literature
Weitere Informationen
Publikationsverlauf
received 08. September 2011
first decision 17. November 2011
accepted 28. November 2011
Publikationsdatum:
10. Februar 2012 (online)
![](https://www.thieme-connect.de/media/eced/201203/lookinside/thumbnails/10.1055-s-0031-1297993-1.jpg)
Abstract
Recent in vitro and in vivo studies have shown a potent inhibition of cytochrome P450 CYP3A4 through human immune deficiency virus (HIV) protease inhibitors (PIs). The PI ritonavir is described as the most potent compound within these CYP3A4 inhibitors. We present 2 cases who developed the sequelae of glucocorticoid excess following ritonavir therapy and inhalative glucocorticoid treatment: A 60-year-old HIV positive man developed the typical symptoms of Cushing’s syndrome and a 52-year-old HIV positive man developed severe osteoporosis.
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