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Arzneimittelforschung 2005; 55(2): 102-106
DOI: 10.1055/s-0031-1296830
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Biological Activity of Some New Flavone Derivatives

Oya Bozdağ-Dündar
a   Ankara University, Faculty of Pharmacy, Departments of Pharmaceutical Chemistry, Ankara, Turkey
,
Meltem Ceylan-Ünlüsoy
a   Ankara University, Faculty of Pharmacy, Departments of Pharmaceutical Chemistry, Ankara, Turkey
,
Nurten Altanlar
b   Ankara University, Faculty of Pharmacy, Departments of Microbiology, Ankara, Turkey
,
Rahmiye Ertan
a   Ankara University, Faculty of Pharmacy, Departments of Pharmaceutical Chemistry, Ankara, Turkey
› Author Affiliations
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Publication History

Publication Date:
23 December 2011 (online)

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Summary

In this study, a new series of 2-{4-[substituted benzylamino-methyl)-phenyl]-4H-benzopyrane-4-one (IVa-e) and N-substituted benzyl-N-[4-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamide (Va-e) derivatives was synthesized and the results of their biological activity are reported. The synthesized compounds were tested for their in vitro antifungal and antibacterial activities. Compound IVa showed the best antifungal activity compared with miconazole (CAS 22916-47-8). Compound IVe indicated the same antibacterial activity compared with the control drug ampicillin (CAS 69-53-4).

Zusammenfassung

Darstellung und antimikrobielle Wirkung neuer Flavon-Derivate

In der vorliegenden Arbeit wurden Derivate von 2-{4-[substituertem Benzyl-amino-methyl)-phenyl]-4H-benzopyrane-4-on (IVa-e) und N-substituertem Benzyl-N-[4-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamid (Va-e) als neue Serie synthetisiert und auf antimykotische und antibakterielle Wirkung untersucht. Die Verbindung IVa zeigte die beste antimykotische Wirkung im Vergleich zu Miconazol (CAS 22916-47-8). Die Substanz IVe zeigte antibakterielle Wirkung, die mit derjenigen von Ampicillin (CAS 69-53-4) vergleichbar war.

Key words:

■Flavone derivatives, antifungal and antimicrobial activities, synthesis