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Arzneimittelforschung 2006; 56(4): 301-308
DOI: 10.1055/s-0031-1296725
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Novel Synthesis of Pyrrolo [2,3-d] pyrimidines Bearing Sulfonamide Moieties as Potential Antitumor and Radioprotective Agents

Magda M. F. Ismail
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
,
Mostafa M. Ghorab
2   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Eman Noaman
3   Department of Biological Radiation, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Yousry A. Ammar
4   Department of Organic Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
,
Helmy I. Heiba
2   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
,
Marwa Y. Sayed
2   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
22 December 2011 (online)

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Summary

A novel series of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties have been synthesized and tested for their antitumor activity. Among them, compounds 4, 8b, 8d, 8g and 14 showed promising antitumor activity. Moreover, compound 8d exhibited radioprotective activity. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data.

Zusammenfassung

Neusynthese von Pyrrolo[2,3-d]pyrimidinen mit Sulfonamid-Resten und mit potentieller Antitumor- und radioprotektiver Wirkung

Eine neue Serie von Pyrrolo[2,3-d] pyrimidinen, die eine Sulfonamid-Rest tragen, wurde synthetisiert und auf Antitumor-Aktivität getestet. Die Verbindungen 4, 8b, 8d und 14 zeigten vielversprechende Antitumor-Aktivität. Zusätzlich zeigte Verbindung 8d eine radioprotektive Wirkung. Die Struktur der neu synthetisierten Verbindungen wurde mittels Elementar-Analyse und Spektraldaten bestimmt.

Key words

Antitumor agents - Pyrrolo[2,3-d]pyrimidines - antitumor and radioprotective activity, synthesis - Pyrrolo[3,2-e][1,2,4] triazolo [4,3-c] pyrimidines - antitumor and - radioprotective activity, synthesis - Radioprotective agents - Sulfonamide moiety