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Arzneimittelforschung 2007; 57(12): 757-761
DOI: 10.1055/s-0031-1296676
DOI: 10.1055/s-0031-1296676
Cardiac Drugs · Cardiac Stimulants · Coronary Drugs
Synthesis and Biological Activity of Thienodiltiazem in Isolated Heart Muscle Preparations of Guinea Pigs
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Publication History
Publication Date:
21 December 2011 (online)
Abstract
The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chro-notropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.