Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000175.xml
Arzneimittelforschung 2007; 57(8): 532-536
DOI: 10.1055/s-0031-1296644
DOI: 10.1055/s-0031-1296644
Antidiabetics
Synthesis and Antidiabetic Activity of Some New Chromonyl-2,4-thiazo-lidinediones
Further Information
Publication History
Publication Date:
21 December 2011 (online)


Abstract
A series of chromonyl-2,4-thiazolidinediones (VIa-f) and chromonyl-2,4-imidazolidinediones (VIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (IVa-f) and substituted benzyl-2,4-imidazolidinediones (Va-f) with chromone-3-carboxaldehyde (I). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds Va, VIb, Vd and VIIe (at lower concentration; 1 μg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose; their effects were lower than that of glibenclamide (CAS 10238-21-8). The activity of the most potent compound (VId) was still 9 % less than that of glibenclamide.