Synthesis and Antidiabetic Activity of Some New Thiazolyl-2,4-thiazolidine-diones

Summary

In this study, a series of thiazolyl-2,4-thi-azolidinediones (VIa-f, VIIa-f and VIIIa-f) was prepared by Knoevenagel reaction of substituted phenacyl-2,4-thiazolidine-diones (IVa-f)/substituted benzyl-2,4-thi-azolidinediones (Va-f) with chlorothiaz-olecarbaldehydes (II, III). The prepared compounds were tested for their insuli-notropic activities in INS-1 cells. A significant insulinotropic effect was seen with compounds VIa, VIb, VIe, VIIa, VIIb and VIIId. Introducing a 2-[(phenylethyl)thio] group into the thiazole ring increased the biological effect, whereas N0₂ groups in phenylacyl or benzyl groups diminished the effects.

Key words

Antidiabetics - Thiazole derivatives - 2,4-Thiazolidinediones, antidiabetic activities, synthesis - Thiazolyl-2,4-thiazolidinediones, antidiabetic activities, synthesis

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