Preeclampsia after chemotherapy for breast cancer during pregnancy–case report and review of the literature

Ziel: The effect of antineoplastic agents on the trophoblast has been discussed to be associated with abnormal placental function such as an increased risk of preeclampsia/eclampsia (Müller T. et al.). We report a further case of a 34 year old gravida 4, para 1 with unilateral invasive breast cancer, treated by surgery and sentinel node excision and subsequently chemotherapy (4 courses cyclophosphamide, 2 courses docetaxel) during pregnancy. Outdoor doppler controls were normal, at 36 + 2 weeks a growth restricted male infant (1680g, < 5th percentile) was born by urgent cesarean section because of acute preeclampsia with pathologic FHF and umbilical enddiastolic reverse flow.

Methodik: Case report and review of the literature as well as consisting data bases.

Ergebnis: We discuss a possible causal relationship between chemotherapy and preeclampsia as well as examine the occurrence of preeclampsia/eclampsia after the application of chemotherapy for breast cancer during pregnancy (German Breast Group GBG–29).

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Preeclampsia - Chemotherapy - Breast cancer