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Int J Sports Med 2012; 33(03): 218-223
DOI: 10.1055/s-0031-1291323
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Exercise Dose Response in Muscle

B. D. Duscha
1   Division of Cardiovascular Medicine, Medicical Center, Duke University, Durham, North Carolina, United States
,
B. H. Annex
2   Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, United States
,
J. L. Johnson
1   Division of Cardiovascular Medicine, Medicical Center, Duke University, Durham, North Carolina, United States
,
K. Huffman
3   Division of Rheumatology, Medical Center, Duke University, Durham, North Carolina, United States
,
J. Houmard
4   Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, United States
,
W. E. Kraus
1   Division of Cardiovascular Medicine, Medicical Center, Duke University, Durham, North Carolina, United States
› Author Affiliations
Further Information

Publication History



accepted after revision 26 September 2011

Publication Date:
19 January 2012 (online)

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Abstract

Exercise increases peak VO2 partially through muscle adaptations. However, understanding muscle adaptations related to exercise dose is incomplete. This study investigated exercise training dose on capillaries per fiber and capillaries per area; and citrate synthase from vastus lateralis and related both to changes in peak VO2. This randomized trial compared 3 exercise doses: low amount-moderate intensity (n=40), low amount-high intensity (n=47), high amount-high intensity (n=41), and a control group (n=35). Both measures of capillary supply increased in all exercise groups (p<0.05). Low amount-high intensity and high amount-high intensity improved citrate synthase (p<0.05) and the low amount-moderate intensity citrate synthase approached significance (p=0.059). Muscle improvements were only related to improvements in peak VO2 in high amount-high intensity (citrate synthase, r=0.304; capillaries:fiber, r= − 0.318; p<0.05 and capillaries/mm2 r= − 0.310, p<0.05). These data suggest muscle adaptations occur following both low and high exercise doses, but are only related to improved peak VO2 following high amount-high intensity training.

Key words

exercise training - capillary density - muscle adaptations - citrate synthase
 

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