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Synlett 2012; 23(11): 1639-1642
DOI: 10.1055/s-0031-1291146
DOI: 10.1055/s-0031-1291146
letter
Synthesis of 4-Quinolones through Nickel-Catalyzed Intramolecular Amination on the β-Carbon of o-(N-Alkylamino)propiophenones
Further Information
Publication History
Received: 09 March 2012
Accepted after revision: 08 April 2012
Publication Date:
13 June 2012 (online)


Abstract
o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information