Biomimetic in situ Regeneration of Cofactors NAD(P)⁺ and NAD(P)H Models Hantzsch Esters and Dihydrophenanthridine

Abstract

Biomimetic recycling of the expensive cofactors NAD(P)H/NAD(P)⁺ and their models is a promising area in bio-inspired synthesis. This paper highlights the recent advances in the in situ regeneration of the oxidized cofactors NAD(P)⁺ through oxidation of cofactors NAD(P)H in the presence of an alcohol dehydrogenase by means of dioxygen and a synthetic Fe(III) porphyrin as a biomimetic NAD(P)H oxidase or flavin as catalyst, and biomimetic in situ regeneration of the expensive NAD(P)H models Hantzsch esters (HEH) and 9,10-dihydrophenanthridine (DHPD) by transition-metal and chiral Brønsted acid catalyzed relay asymmetric hydrogenation.

1. Introduction

2. Biomimetic in situ Regeneration of NAD(P)⁺

3. Biomimetic in situ Regeneration of Hantzsch Esters (HEH)

4. Biomimetic in situ Regeneration of Dihydrophenanthridine (DHPD)

5. Future Perspective

Key words

biomimetic - regeneration - asymmetric hydrogenation - Hantzsch esters - dihydrophenanthridine

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