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Synthesis 2012; 44(11): 1663-1666
DOI: 10.1055/s-0031-1290986
DOI: 10.1055/s-0031-1290986
paper
Protecting Group-Free Syntheses of (4S,5S,11R)- and (4S,5S,11S)-iso-Cladospolide B and Their Biological Evaluation
Further Information
Publication History
Received: 20 February 2012
Accepted after revision: 03 April 2012
Publication Date:
09 May 2012 (online)
Abstract
Short and efficient total syntheses of (4S,5S,11R)- and (4S,5S,11S)-iso-cladospolide B were achieved in five steps each without using any protecting groups. The key steps were an alkyne-zipper reaction, a Suzuki cross coupling, and a Sharpless asymmetric dihydroxylation. The biological activities of both natural products toward various cancer cell lines were tested for the first time.
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