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Synlett 2012; 23(9): 1327-1330
DOI: 10.1055/s-0031-1290937
DOI: 10.1055/s-0031-1290937
letter
Synthetic Study of the Angular Tetracyclic Core Skeleton of Landmycine A via Masamune–Bergman Cyclization
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Publikationsverlauf
Received: 13. Februar 2012
Accepted after revision: 13. März 2012
Publikationsdatum:
14. Mai 2012 (online)


Abstract
We describe the synthesis, via Masamune–Bergman cyclization, of an angucycline derivative involving a quinone in the B ring and a nonaromatic hydroxylated C ring. The naphthoquinone was synthesized via the copper-catalyzed Ullmann reaction of the dihalo aryl moiety, and the subsequent oxidation of a corresponding hydroquinone. The aryl dihalide was prepared by the dihalogenation of the 1,4-diradical generated during the Masamune–Bergman cyclization of the 1,2- dialkynylbenzene under neutral conditions. This methodology suggests a new route for the construction of natural products containing an anthraquinone skeleton.
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- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
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