Highly Efficient Synthesis of Novel Morita–Baylis–Hillman Adducts from Activated Ketones Using a DABCO-Based Hydroxy Ionic Liquid (HIL) as a Recyclable Catalyst-Solvent

Abstract

A highly efficient non-imidazolium DABCO-based ionic liquid has been prepared for the synthesis of biologically active Morita–Baylis–Hillman adducts from activated ketones. The results show that the ionic liquid is very efficient in the Morita–Baylis–Hillman reaction due to its operational simplicity, high yields, dual catalyst-solvent properties, and excellent recyclability and reusability. This hydroxy ionic liquid acts as a protic solvent and tertiary amine for the preparation of biologically active compounds from isatin, ninhydrin, 1,2-acenaphthylenequinone, and benzil with high yields and very short reaction times.

Key words

ionic liquid - Morita–Baylis–Hillman reaction - DABCO­ - activated ketone - solvent-catalyst system

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