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Synlett 2012; 23(8): 1103-1107
DOI: 10.1055/s-0031-1290765
DOI: 10.1055/s-0031-1290765
synpacts
The Use of Tertiary Alkylmagnesium Nucleophiles in Ni-Catalyzed Cross-Coupling Reactions
Further Information
Publication History
Received: 23 January 2012
Accepted: 08 February 2012
Publication Date:
20 April 2012 (online)
Abstract
Nickel-catalyzed cross-coupling reactions of unactivated tertiary alkyl nucleophiles and aryl bromides have been developed using N-heterocyclic carbene ligands. These processes are reviewed alongside earlier attempts to employ unactivated tertiary alkyl nucleophiles in cross-coupling reactions. Potential mechanisms for the transformations, and future challenges in this field are discussed.
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References and Notes
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