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Synlett 2012; 23(15): 2279-2283
DOI: 10.1055/s-0031-1290456
DOI: 10.1055/s-0031-1290456
letter
100 Gram Scale Synthesis of a Key Intermediate of Matrix Metalloproteinase Inhibitor in a Continuous-Flow System Based on a Copper-Free Sonogashira Reaction Using an Ionic Liquid as a Catalyst Support
Weitere Informationen
Publikationsverlauf
Received: 30. Mai 2012
Accepted after revision: 28. Juni 2012
Publikationsdatum:
14. August 2012 (online)


Abstract
The key intermediate of matrix metalloproteinase (MMP) inhibitor was synthesized using a flow microreactor for a copper-free Sonogashira coupling reaction in an ionic liquid. The ionic liquid [emim]NTf2 was used as a solvent and a catalyst support. A 100 g scale synthesis was achieved in combination with a flow-extraction/catalyst-recycling system, in which the ionic liquid containing the palladium catalyst was continuously recycled.