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Synlett 2012; 23(12): 1805-1808
DOI: 10.1055/s-0031-1290404
DOI: 10.1055/s-0031-1290404
letter
‘Evans Auxiliary’ Based P–N Ligands for Pd-Catalyzed Asymmetric Allylic Alkylation Reactions
Further Information
Publication History
Received: 16 April 2012
Accepted after revision: 06 May 2012
Publication Date:
14 June 2012 (online)


Abstract
A new type of chiral P–N ligands has been prepared which incorporates the Evans auxiliary as chiral ligand. They were found to act as effective ligands in the Pd-catalyzed allylic alkylation reactions. Using these ligands with allylpalladium chloride dimer as catalyst, the coupling of 1,3-diphenyl-3-acetoxyprop-1-ene and dimethyl malonate proceeded smoothly at –10 °C providing the desired product with enantiomeric excess up to 87% and excellent yield.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information