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Synthesis 2012; 44(15): 2413-2423
DOI: 10.1055/s-0031-1290384
DOI: 10.1055/s-0031-1290384
paper
Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides
Further Information
Publication History
Received: 28 March 2012
Accepted after revision: 09 May 2012
Publication Date:
19 June 2012 (online)
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Abstract
N-Aryl-O-alkylhydroxamic acid derivatives were prepared by copper-catalyzed cross-coupling of hydroxamates with aryl iodides. The reaction conditions are compatible with standard hydroxy-protecting groups on the hydroxylamine moiety and are applicable to a broad range of coupling partners.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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For recent examples, see:
For recent examples, see:
For selected examples, see:
For recent examples, see:
For detailed studies on the mechanism of the Cu-catalyzed N-arylation reaction, see:
For X-ray crystallographic data for complexes of allyl group containing compounds with copper, see: