Abstract
This Account summarizes predominately our own experiences in
developing microwave-heated palladium-catalyzed Mo(CO)6 -mediated
gas-free carbonylative reactions, although contributions from other
groups, including non-palladium-catalyzed examples, have also been
covered. Presented reactions include amino-, amido-, and alkoxycarbonylations
as well as carbonylative cyclizations and carbonylative cross-couplings,
using Mo(CO)6 as a solid source of CO. The methodology
was developed mainly for rapid small-scale applications, avoiding
the problematic use of gaseous CO in a standard laboratory. In most
cases, the reported Mo(CO)6 -mediated carbonylations were
conducted in sealed vessels and with reaction times of less than
1 hour. The Account also highlights relevant applications in medicinal
and high-speed chemistry.
1 Introduction
2 Mo(CO)6 -Promoted Carbonylations - The
Beginning
3 Aminocarbonylations
4 Amidocarbonylations
5 Alkoxy- and Hydroxycarbonylations
6 Carbonylative Ring Closing of Aryl Halides
7 Carbonylative Cross-Couplings
8 Palladium-Free Mo(CO)6 -Promoted Carbonylations
9 Summary and Outlook
Key words
carbonylation - molybdenum - multicomponent
reaction - palladium - catalysis
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