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Synlett 2012(4): 642-643
DOI: 10.1055/s-0031-1290334
DOI: 10.1055/s-0031-1290334
SPOTLIGHT
© Georg Thieme Verlag
Stuttgart ˙ New York
Zinc Borohydride
Further Information
Publication History
Publication Date:
13 February 2012 (online)
![](https://www.thieme-connect.de/media/synlett/201204/lookinside/thumbnails/10.1055-s-0031-1290334-1.jpg)
Introduction
Zinc borohydride is a neutral reagent employed for the reduction of several types of carbonyl compounds. It is commercially available, but it is also easily prepared by reacting ZnCl2 with NaBH4. [¹] Kotsuki et al. described the selective reduction of thioesters in the presence of other functional groups using Zn(BH4)2 [¹] and Oishi and Nakata described the reduction of chiral β-keto esters with Zn(BH4)2 leading to the corresponding alcohols with high stereoselectivity. [²] This Spotlight summarizes further reactions of zinc borohydride.
- 1
Kotsuki H.Yoshimura N.Ushio Y.Ohtsuka T.Ochi M. Chem. Lett. 1986, 1003 - 2
Oishi T.Nakata T. Acc. Chem. Res. 1984, 17: 338 - 3
Ranu BC.Majee A.Sarkar A. J. Org. Chem. 1998, 63: 370 - 4
Yakura T.Yoshimoto Y.Ishida C.Mabuchi S. Tetrahedron 2007, 63: 4429 - 5
Dias LC.Fattori J.Perez CC.de Oliveira VM.Aguilar AM. Tetrahedron 2008, 64: 5891 - 6
Liu LX.Xião KJ.Huang PQ. Tetrahedron 2009, 65: 3834 - 7
Gao D.O’Doherty GA. J. Org. Chem. 2005, 70: 9932 - 8
Zhang D.Chen Z.Cai H.Zou X. J. Fluorine Chem. 2009, 130: 938 - 9
Hong S.Yang J.Weinreb SM. J. Org. Chem. 2006, 71: 2078