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Synlett 2012(2): 239-242
DOI: 10.1055/s-0031-1290121
DOI: 10.1055/s-0031-1290121
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
α-Formylation of α-Substituted Ketones
Weitere Informationen
Received
1 November 2011
Publikationsdatum:
22. Dezember 2011 (online)
Publikationsverlauf
Publikationsdatum:
22. Dezember 2011 (online)
![](https://www.thieme-connect.de/media/synlett/201202/lookinside/thumbnails/10.1055-s-0031-1290121-1.jpg)
Abstract
The reaction of (chloromethylene)dimethylammonium chloride (generated in situ from oxalyl chloride and DMF) with α-substituted ketones in CH2Cl2, followed by workup with aqueous NaHCO3, gave β-keto aldehydes containing an α-quaternary centre (8-88% yield).
Key words
aldehydes - enols - hydrolysis - ketones - tautomerism
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