Iron-Mediated Cyanation of
Methoxybenzene, Indole, and 2-Arylpyridine C-H
Bonds

Guangyou Zhang; Guanglei Lv; Changduo Pan; Jiang Cheng; Fan Chen

doi:10.1055/s-0031-1289883

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Synlett 2011(20): 2991-2994
DOI: 10.1055/s-0031-1289883

LETTER

Iron-Mediated Cyanation of Methoxybenzene, Indole, and 2-Arylpyridine C-H Bonds

Guangyou Zhang^a, Guanglei Lv^a, Changduo Pan^b, Jiang Cheng^a, Fan Chen*^a
^a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325000, P. R. of China
Fax: +86(577)56998939; e-Mail: fanchen@wzu.edu.cn;
^b Wenzhou Institute of Industry & Science, Wenzhou 325000, P. R. of China

Further Information

Publication History

Received 4 September 2011
Publication Date:
11 November 2011 (online)

Abstract
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References
Supplementary Material

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Abstract

An iron-mediated direct cyanation of indole and 2-arylpyridine C-H bonds is described. Notably, trimethoxybenzene reacted smoothly under the procedure, forming a C-CN bond via C-H bond cleavage without chelation assistance.

Key words

iron - indole - 2-arylpyridine - C-H activation - cyanation

Supporting Information

References and Notes

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Supplementary Material

Supporting Information