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Synthesis 2012(8): 1237-1246  
DOI: 10.1055/s-0031-1289731
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Sulfanylation of 4-Quinazolinone via C-OH Bond Activation: An Efficient Route to 2-Aryl-4-sulfanylquinazolines

Yiyuan Peng*a, Guanyinsheng Qiub, Qin Yanga, Jianjun Yuana, Zhihong Dengb
a Key Laboratory of Small Fuctional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China
Fax: +86(791)88120396; e-Mail: yypeng@jxnu.edu.cn; e-Mail: Yiyuanpeng@yahoo.com;
b Key Laboratory of Green Chemistry, Jiangxi Province and College of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China
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Publikationsverlauf

Received 3 January 2012
Publikationsdatum:
01. März 2012 (online)

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Abstract

The direct sulfanylation of 2-aryl-4-quinazolinones with thiols via C-OH bond activation under mild conditions is described. The method affords the corresponding 2-aryl-4-sulfanylquinazolines in good to excellent yield.

Key words

nitrogen heterocycles - multicomponent reactions - sulfinylations - thiols - bond activation

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