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Synlett 2011(18): 2671-2674
DOI: 10.1055/s-0031-1289547
DOI: 10.1055/s-0031-1289547
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
TAPC-Promoted Synthesis of Sulfonyl Chlorides from Sulfonic Acids
Further Information
Received
15 August 2011
Publication Date:
19 October 2011 (online)
Publication History
Publication Date:
19 October 2011 (online)
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Abstract
A novel and efficient method is described for the preparation of sulfonyl chlorides from sulfonic acids using TAPC as chlorinating agent. Mild reaction conditions, shorter reaction times, high efficiencies, cost-effectiveness, and facile isolation of the desired products make the present methodology a practical alternative and will provide a valuable synthetic tool for various pharmaceutical applications.
Key words
sulfonyl chlorides - sulfonic acids - chlorinating agent - solvent-free conditions - 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-hexachloride (TAPC)
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