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DOI: 10.1055/s-0031-1289512
N-Methylimidazole: Attractive and Valuable Chameleonic Species
Publikationsverlauf
Publikationsdatum:
06. Oktober 2011 (online)
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Introduction
In the last decades N-methylimidazole (N-Mim) has attracted the attention of a great number of research groups due to its broad chameleonic behavior, being widely used in organic chemistry as a solvent, as co-catalyst, ligand in metal complexes, Brønsted or Lewis base catalyst. N-Mim participates in the active center of several enzymes, as an ionic liquid precursor, as electron acceptor or as key intermediate in synthesis. [¹-7] On the other hand, the chemistry of imidazole compounds in general has been also a center of interest due to the presence of its essential functional unit in a large variety of biological important molecules, being the N-methylimidazole used to mimic aspects of several of these biomolecules. [8] These derivatives can be helpful in studies to elucidate biological mechanisms, and its importance has led to several international patents. The different roles played by N-methylimidazole have been extensively applied for the synthesis of important targets. [8]
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