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Dtsch Med Wochenschr 2011; 136(37): 1865-1868
DOI: 10.1055/s-0031-1286357
DOI: 10.1055/s-0031-1286357
Prinzip & Perspektive | Review article
Grundlagenforschung
© Georg Thieme Verlag KG Stuttgart · New York
Der Modellorganismus Zebrafisch in der biomedizinischen Grundlagenforschung: Anwendungen und Perspektiven in der vaskulären Biologie und Medizin
The model organism zebrafish in biomedical research: applications and perspectives in vascular biology and medicineFurther Information
Publication History
eingereicht: 5.5.2011
akzeptiert: 14.7.2011
Publication Date:
06 September 2011 (online)
Schlüsselwörter
Zebrafisch - Vaskuläre Entwicklung und Funktion - Funktionelle Analyse von Genen - Tumorangiogenese - Bildgebung
Keywords
zebrafish - vascular development and function - loss-of-function and gain-of-function experiments - tumor angiogenesis - imaging
Literatur
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- 3 Ausoni S, Sartore S. From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. J Cell Biol. 2009; 184 357-364
- 4 Bussmann J, Wolfe S A, Siekmann A F. Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling. Development. 2011; 138 1717-1726
- 5 Ellertsdottir E, Lenard A, Blum Y. et al . Vascular morphogenesis in the zebrafish embryo. Dev Biol. 2010; 341 56-65
- 6 Epting D, Wendik B, Bennewitz K, Dietz C T, Driever W, Kroll J. The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Circ Res. 2010; 107 45-55
- 7 Kuchler A M, Gjini E, Peterson-Maduro J, Cancilla B, Wolburg H, Schulte-Merker S. Development of the zebrafish lymphatic system requires VEGFC signaling. Curr Biol. 2006; 16 1244-1248
- 8 Nicoli S, Presta M. The zebrafish/tumor xenograft angiogenesis assay. Nat Protoc. 2007; 2 2918-2923
- 9 Stoll S J, Bartsch S, Augustin H G, Kroll J. The Transcription Factor HOXC9 Regulates Endothelial Cell Quiescence and Vascular Morphogenesis in Zebrafish via Inhibition of Interleukin 8. Circ Res. 2011; 108 1367-1377
- 10 Tran T C, Sneed B, Haider J. et al . Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res. 2007; 67 11386-11392
Priv.-Doz. Dr. Jens Kroll
Centrum für Biomedizin und Medizintechnik
Mannheim (CBTM)
Abt. Vaskuläre Biologie und
Tumorangiogenese
Medizinische Fakultät Mannheim
der Universität Heidelberg
Ludolf-Krehl-Str.
13–17
68167 Mannheim
Phone: 0621/383-9965
Fax: 0621/383-9961
Email: kroll@angiogenese.de
URL: http://www.angiolab.de