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Klinische Neurophysiologie 2011; 42(04): 250-251
DOI: 10.1055/s-0031-1285902
Posterpreisträger der DGKN-Jahrestagung
© Georg Thieme Verlag KG Stuttgart · New York

Changes in Excitability of the Human Motor Cortex Face Area by Observing Speech

Veränderungen in der Erregbarkeit des menschlichen Motorkortex Gesichtsareals während Sprachbeobachtung
T. Murakami
1   Department of Neurology, Goethe-University, Frankfurt am Main, Germany
,
J. Restle
1   Department of Neurology, Goethe-University, Frankfurt am Main, Germany
,
U. Ziemann
1   Department of Neurology, Goethe-University, Frankfurt am Main, Germany
› Author Affiliations
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Publication History

Publication Date:
05 December 2011 (online)

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Introduction

Language is the most important communicative tool with substantial evolution in the process of human phylogenetic development. Language processing in humans occurs in a distributed network of brain areas including the superior temporal gyrus which functionally links with the posteroinferofrontal area (including Broca’s area) and the dorsolateral premotor area. This network forms a sensory-motor transformation pathway to map speech perception onto speech production processes [1] [2], which has strong overlap with the putative mirror neuron system (MNS). The MNS is considered to play an important role in unifying action perception and motor execution. The theory of perception-execution matching predicts that observation of motor action should lead to an increase of excitability in the primary motor cortex (M1) representations involved in the observed action. Indeed, motor evoked potential (MEP) amplitude in hand muscles increases during observation of hand and arm movements [3] [4], and MEP amplitude of facial muscles involved in speech production increases when observing speech-related lip movements [5] [6], or even when listening to speech [6] [7]. Furthermore, recent studies also provided evidence for a role of inhibitory mechanisms to prevent overt motor activation during action observation [8] [9].

In this study, we investigated mechanisms of the putative human MNS related to speech perception using focal transcranial magnetic stimulation (TMS) focusing on effector and task specificity and correlation with task difficulty. Effector and task specific inhibitory control mechanisms were also investigated.

 

  • References

  • 1 Hickok G, Poeppel D. Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition 2004; 92: 67-99
    CrossrefPubMedSearch in Google Scholar
  • 2 Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci 2004; 27: 169-192
    CrossrefPubMedSearch in Google Scholar
  • 3 Fadiga L, Fogassi L, Pavesi G et al. Motor facilitation during action observation: a magnetic stimulation study. J Neurophysiol 1995; 73: 2608-2611
    PubMedSearch in Google Scholar
  • 4 Patuzzo S, Fiaschi A, Manganotti P. Modulation of motor cortex excitability in the left hemisphere during action observation: a single- and paired-pulse transcranial magnetic stimulation study of self- and non-self-action observation. Neuropsychologia 2003; 41: 1272-1278
    CrossrefPubMedSearch in Google Scholar
  • 5 Sundara M, Namasivayam AK, Chen R. Observation-execution matching system for speech: a magnetic stimulation study. Neuroreport 2001; 12: 1341-1344
    CrossrefPubMedSearch in Google Scholar
  • 6 Watkins KE, Strafella AP, Paus T. Seeing and hearing speech excites the motor system involved in speech production. Neuropsychologia 2003; 41: 989-994
    CrossrefPubMedSearch in Google Scholar
  • 7 Fadiga L, Craighero L, Buccino G et al. Speech listening specifically modulates the excitability of tongue muscles: a TMS study. Eur J Neurosci 2002; 15: 399-402
    CrossrefPubMedSearch in Google Scholar
  • 8 Kraskov A, Dancause N, Quallo MM et al. Corticospinal neurons in macaque ventral premotor cortex with mirror properties: a potential mechanism for action suppression?. Neuron 2009; 64: 922-930
    CrossrefPubMedSearch in Google Scholar
  • 9 Mukamel R, Ekstrom AD, Kaplan J et al. Single-Neuron Responses in Humans during Execution and Observation of Actions. Curr Biol 2010; 20: 750-756
    CrossrefPubMedSearch in Google Scholar
  • 10 Fadiga L, Craighero L, D’Ausilio A. Broca’s area in language, action, and music. Ann N Y Acad Sci 2009; 1169: 448-458
    CrossrefPubMedSearch in Google Scholar
  • 11 Liberman AM, Cooper FS, Shankweiler DP et al. Perception of the speech code. Psychol Rev 1967; 74: 431-461
    CrossrefPubMedSearch in Google Scholar
  • 12 Liberman AM, Whalen DH. On the relation of speech to language. Trends Cogn Sci 2000; 4: 187-196
    CrossrefPubMedSearch in Google Scholar
  • 13 Rizzolatti G, Arbib MA. Language within our grasp. Trends Neurosci 1998; 21: 188-194
    CrossrefPubMedSearch in Google Scholar
  • 14 Datta AK, Harrison LM, Stephens JA. Task-dependent changes in the size of response to magnetic brain stimulation in human first dorsal interosseous muscle. J Physiol (Lond) 1989; 418: 13-23
    PubMedSearch in Google Scholar
  • 15 Pearce AJ, Kidgell DJ. Corticomotor excitability during precision motor tasks. J Sci Med Sport 2009; 12: 280-283
    CrossrefPubMedSearch in Google Scholar
  • 16 Murakami T et al Observation-execution matching and action inhibituion in human primary motor cortex during viewing of speech-related lip movements or listening to speech. Neuropsychologia 2011; 49: 2045-2054
    CrossrefPubMedSearch in Google Scholar