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DOI: 10.1055/s-0031-1284366
Hypopituitarism in a HIV Affected Patient
Publikationsverlauf
received 01. Januar 2011
firstdecision 28. Mai 2011
accepted 12. Juli 2011
Publikationsdatum:
15. September 2011 (online)
![](https://www.thieme-connect.de/media/eced/201110/lookinside/thumbnails/10.1055-s-0031-1284366-1.jpg)
Abstract
Background:
The clinical picture of pituitary abscesses may resemble features of other pituitary pathologies including endocrine deficiencies. The characteristic radiological changes, namely the ring enhancement, may aid in the diagnostic work-up of this very rare condition.
Case Report:
A 40-year-old patient with longstanding HIV infection presented with headache and fatigue. Testing for pituitary function confirmed panhypopitutarism. MRI scanning demonstrated an inhomogeneous pituitary gland with ring-like enhancement and sphenoid sinus mucosa thickening. Transsphenoidal surgery was performed. Histologically CD68 positive macrophages were found supporting the diagnosis of infectious hypophysitis. Under hormone replacement therapy and retroviral treatment the patient clinically normalized.
Conclusion:
A pituitary abscess due to infectious hypophysitis is a rare cause of pituitary failure. Diagnostic signs on imaging may help to rapidly distinguish the cause of pituitary deficiency in patients with HIV infection.
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