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Semin Respir Crit Care Med 2011; 32(4): 527-540
DOI: 10.1055/s-0031-1283289
Published by Thieme Medical Publishers

Progress in Respiratory Virus Vaccine Development

Alexander C. Schmidt1
  • 1Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Publication History

Publication Date:
19 August 2011 (online)

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ABSTRACT

Viral respiratory infections cause significant morbidity and mortality in infants and young children as well as in at-risk adults and the elderly. Although many viral pathogens are capable of causing respiratory disease, vaccine development has to focus on a limited number of pathogens, such as those that commonly cause serious lower respiratory illness (LRI). Whereas influenza virus vaccines have been available for some time (see the review by Clark and Lynch in this issue), vaccines against other medically important viruses such as respiratory syncytial virus (RSV), the parainfluenza viruses (PIVs), and metapneumovirus (MPVs) are not available. This review aims to provide a brief update on investigational vaccines against RSV, the PIVs, and MPV that have been evaluated in clinical trials or are currently in clinical development.

KEYWORDS

Vaccine - parainfluenza virus - metapneumovirus - respiratory syncytial virus - clinical trial - clinical development

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Alexander C SchmidtM.D. 

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health

50 South Dr., Rm. 6511, Bethesda, MD 20892-8007

Email: schmidta@niaid.nih.gov