New Lanostane Triterpenoids from Antrodia camphorata

Many polypores are used for medicinal purposes in traditional Chinese medicine. Antrodia camphorata (M. Zang et C.H. Su) Sheng H. Wu, Rywarden et T.T. Chang, known as „niu-chang-chih“, is restricted to the endemic tree, Cinnamomum kanehirae Hayata. Traditionally the fungus has been used for the treatment of food and drug intoxication, diarrhea, abdominal pain, hypertension, skin itching, and liver cancer. The components of this fungi have shown activities such as anti-inflammation, immune-modulation, anti-Helicobacter pylori, and neuroprotection from Aβ damage. Here, we present our chemical studies on the mixture of fruiting body and mycelia of solid cultures of A. camphorata. As a result, eight new lanostane triterpenoids, 3,7,11-trioxo- 5α-lanosta-8,24-(E)-dien-26-oic acid (1), methyl 11α-hydroxy-3,7-dioxo-5α-lanosta-8,24-(E)-dien-26-oate (2), methyl 3,7,11,12,15,23-hexaoxo-5α-27ζ-lanost-8-en-26-oate (3), ethyl 3,7,11,12,15,23-hexaoxo-5α-27ζ-lanost-8-en-26-oate (4), ethyl lucidenate A (5), ethyl lincidenate F (6), acetyl ganolucidic acid A (7), 3,11,15,23-tetraoxo- 5α-27ζ-lanosta-8,16-dienoic acid (8), were isolated and elucidated. These compounds were evaluated for their cytotoxicity against several human tumor cell lines.