Fortschr Neurol Psychiatr 2012; 80(6): 320-326
DOI: 10.1055/s-0031-1281846
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Was wird aus Kindern mit fetalem Alkoholsyndrom (FAS)/fetalen Alkoholspektrumstörungen (FASD) im Erwachsenenalter?

What is Known About the Outcome as Adults for Children with Fetal Alcohol Syndrome (FAS)/Fetal Alcohol Spectrum Disorders (FASD)?
J. E. Walloch
,
P. H. Burger
,
J. Kornhuber
Further Information

Publication History

Publication Date:
15 December 2011 (online)

Zusammenfassung

Den durch mütterlichen pränatalen Alkoholkonsum verursachten psychischen Beeinträchtigungen wird in der deutschsprachigen Erwachsenenpsychiatrie noch wenig Aufmerksamkeit geschenkt. Dabei werden Kinder von alkoholkranken Schwangeren im Erwachsenenalter selbst mit vielfältiger Symptomatik in psychiatrischen Institutionen vorstellig, unter anderem mit Aufmerksamkeitsdefizitstörungen, affektiven Störungen oder Intelligenzminderung. Zugrunde liegende fetale Alkoholspektrumstörungen werden jedoch selten diagnostiziert. Eine leitliniengerechte Therapie existiert nicht. Aktuelle Übersichtsarbeiten im deutschsprachigen Raum entstammen meist der Kinder- und Jugendmedizin bzw. -psychiatrie. In der folgenden Arbeit soll im Rahmen einer ausgewählten Literaturübersicht die Krankheitsentität der fetalen Alkoholspektrumstörungen bzw. des fetalen Alkoholsyndroms und deren Bedeutung für die Erwachsenpsychiatrie dargestellt und diskutiert sowie auf noch offene Fragen sowie Forschungsbedarf, z. B. die Entwicklung von Diagnoseinstrumenten oder die Etablierung diagnostischer Kategorien, hingewiesen werden.

Abstract

In the field of adult psychiatry in German-speaking countries, little attention is as yet paid to the psychic defects that a fetus can sustain as a result of prenatal exposure to alcohol. Although children of alcohol-dependent mothers do present to psychiatric institutions as adults with manifold symptoms, e. g., attention deficit disorders, affective disorders or intellectual disability, fetal alcohol spectrum disorders are rarely diagnosed as an underlying cause. Appropriate therapy guidelines do not exist. Current review papers within the German-speaking countries usually stem from paediatric and adolescent psychiatry or medicine. Based on a selected review of the literature, the following paper addresses and discusses the disease entity of fetal alcohol spectrum disorders and fetal alcohol syndrome and their significance for adult psychiatry and also identifies open questions and research requirements, e. g., the development of diagnostic instruments or the establishment of diagnostic categories.

 
  • Literatur

  • 1 Blum A, Löser H. Diagnose der Alkoholembryopathie. Dtsch Med Wschr 1995; 120: 184-189
  • 2 Burd L, Martsolf JT. Fetal Alcohol Syndrome: Diagnosis and Syndromal Variability. Physiology & Behavior 1989; 46: 39-43
  • 3 Famy C, Streissguth AP, Unis AS. Mental Illness in Adults With Fetal Alcohol Syndrome or Fetal Alcohol Effects. Am J Psychiatry 1998; 155 (04) 552-554
  • 4 Spohr H-L, Steinhausen H-C. Fetale Alkohol-Spektrum-Störungen. Deutsches Ärzteblatt 2008; 11: 529-534
  • 5 Mukherjee R, Turk J. Fetal alcohol syndrome. The Lancet 2004; 363: 1556-1556
  • 6 Streissguth AP, O’Malley K. Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. Semin Clin Neuropsychiatry 2000; 5 (03) 177-190
  • 7 Astley SJ. Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network. Can J Clin Pharmacol 2010; 17 (01) 132-164
  • 8 Burd L, Klug MG, Li Q et al. Diagnosis of fetal alcohol spectrum disorders: a validity study of the fetal alcohol syndrome checklist. Alcohol 2010; 44: 605-614
  • 9 Hoyme HE, May PA, Kalberg WO et al. A Practical Clinical Approach to Diagnosis of Fetal Alcohol Spectrum Disorders: Clarification of the 1996 Institute of Medicine Criteria. Pediatrics 2005; 115: 39-47
  • 10 Spohr HL. Fetal alcohol syndrome in adolescence: long-term perspective of children diagnosed in infancy. In: Spohr HL, Steinhausen HC, (Hrsg) Alcohol, pregnancy and the developing child. 1. Aufl. Cambridge University Press; 1996: 207-226
  • 11 Manning MA, Hoyme EH. Fetal alcohol spectrum disorders: a practical clinical approach to diagnosis. Neurosci Biobehav Res 2007; 31 (02) 230-238
  • 12 Greenbaum R, Nulman I, Rovet J et al. The Toronto experience in diagnosing alcohol-related neurodevelopmental disorder: a unique profile of deficits and assets. Can J Clin Pharmacol 2002; 9 (04) 215-225
  • 13 Mattson SN, Roesch SC, Fagerlund A et al. Toward a Neurobehavioral Profile of Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res 2010; 34 (09) 1640-1650
  • 14 Barr HM, Streissguth AP. Identifying maternal self-reported alcohol use associated with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 2001; 25 (02) 283-287
  • 15 Rasmussen C, Benz J, Pei Jal. The impact of an ADHD co-morbidity on the diagnosis of FASD. Can J Clin Pharmacol 2010; 17 (01) 165-176
  • 16 Burd L, Klug MG, Martsolf JT et al. Fetal alcohol syndrome: neuropsychiatric phenomics. Neurotoxicol Teratol 2003; 25 (06) 697-705
  • 17 O’Connor MJ, Paley B. Psychiatric Conditions Associated With Prenatal Alcohol Exposure. Dev Disabil Res Rev 2009; 15: 225-234
  • 18 Bühring P. Fetales Alkoholsyndrom – Zu hundert % vermeidbar. Deutsches Ärzteblatt 2008; 11: 512-512
  • 19 Feldmann R. FAS-Ambulanz . Münster: www.fetales-alkoholsyndrom.de
  • 20 Streissguth AP, Aase JM, Clarren SK et al. Fetal alcohol syndrome in adolescents and adults. JAMA 1991; 265: 1961-1967
  • 21 Burd L, Carlson C, Kerbeshian J. Fetal alcohol spectrum disorders and mental illness. Int J Disabil Hum Dev 2007; 6: 383-396
  • 22 O’Malley KD, Nanson J. Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. Can J Psychiatry 2002; 47: 349-354
  • 23 Barr HM, Bookstein FL, O’Malley KD et al. Binge drinking during pregnancy as a predictor of psychiatric disorders on the Structured Clinical Interview for DSM-IV in young adult offspring. Am J Psychiatry 2006; 163 (06) 1061-1065
  • 24 Huggins JE, Grant T, O’Malley K et al. Suicide Attempts Among Adults With Fetal Alcohol Spectrum Disorders: Clinical Considerations. Mental Health Aspects of Developmental Disabilities 2008; 11 (02) 33-41
  • 25 Baer JS, Scampson PD, Barr HM et al. A 21-Year Longitudinal Analysis of the Effects of Prenatal Alcohol Exposure on Young Adult Drinking. Arch Gen Psychiatry 2003; 60: 377-385
  • 26 Alati R, Al Mamun A, Williams GM et al. In Utero Alcohol Exposure and Prediction of Alcohol Disorders in Early Adulthood. Arch Gen Psychiatry 2006; 63: 1009-1016
  • 27 Roebuck TM, Mattson SN, Riley EP. Behavioral and psychosocial profiles of alcohol exposed children. Alcohol Clin Exp Res 1999; 23: 1070-1076
  • 28 Streissguth AP, Bookstein FL, Barr HM et al. Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. J Dev Behav Pediatr 2004; 25 (04) 228-238
  • 29 Streissguth AP, Barr HM, Kogan J et al. Understanding the occurrence of secondary disabilities in clients with fetal alcohol syndrome (FAS) and fetal alcohol effects (FAE). Final Report to the Centers for Disease Control and Prevention (CDC). Seattle, University of Washington, Fetal Alcohol and Drug Unit 1996; 96-06
  • 30 Majewski EF. Clinical symptoms in patients with fetal alcohol syndrome. In: Spohr HL, Steinhausen HC, (Hrsg) Alcohol, pregnancy and the developing child. 1. Aufl. Cambridge University Press; 1996: 15-39
  • 31 Band LC, West JR. Neuropathology in experimental fetal alcohol syndrome. In: Spohr HL, Steinhausen HC, Hrsg. Alcohol, pregnancy and the developing child. Cambridge University Press; 1996: 103-122
  • 32 Bookstein FL, Streissguth AP, Sampson PD et al. Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure. Neuroimage 2002; 15: 233-251
  • 33 Coles CD, Goldstein FC, Lynch ME et al. Memory and brain volume in adults prenatally exposed to alcohol. Brain Cogn 2011; 75 (01) 67-77
  • 34 Coles CD, Lynch ME, Kable JA et al. Verbal and Nonverbal Memory in Adults Prenatally Exposed to Alcohol. Alcohol Clin Exp Res 2010; 34 (05) 897-906
  • 35 American Psychiatric Association. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-IV. Deutsche Bearbeitung von Saß H, Wittchen HU 4. Aufl. Göttingen: Hogrefe; 1996
  • 36 WHO (Hrsg) Internationale Klassifikation psychischer Störungen. ICD-10, Klinisch, Diagnostische Leitlinien. 4. Aufl. Bern: Huber;
  • 37 Burger PH, Goecke TW, Fasching M et al. Einfluss des mütterlichen Alkoholkonsums während der Schwangerschaft auf die Entwicklung von ADHS beim Kind. Fortschr Neurol Psychiat 2011; 79: 1-7
  • 38 Spohr HL, Willms J, Steinhausen HC. Prenatal alcohol exposure and long-term developmental consequences. Lancet 1993; 341: 907-910
  • 39 Streissguth AP, Bookstein FL, Barr HM. A dose-response study of the enduring effects of prenatal alcohol exposure: birth to 14 years. In: Spohr HL, Steinhausen HC, (Hrsg) Alcohol, pregnancy and the developing child. 1. Aufl. Cambridge University Press; 1996: 141-168
  • 40 Mukherjee R, Eastman N, Turk J et al. Fetal alcohol syndrome: law and ethics. The Lancet 2007; 369: 1149-1150
  • 41 Fas-world Deutschland. Verein von Eltern, Pädagogen, Medizinern, Therapeuten, die sich mit FASD beschäftigen. www.fasworld.de
  • 42 Giseke S. Fetales Alkoholsyndrom, Hilfe nach langer Odyssee. Deutsches Ärzteblatt 2007; 12: 553-553
  • 43 Grant TM, Ernst CC, Streissguth AP et al. When case management isn’t enough: a model of paraprofessional advocacy for drug- and alcohol-abusing mothers. J Case Manag 1996; 5 (1) 3-11
  • 44 Grant T, Huggins J, Connor P et al. A pilot community intervention for young women with fetal alcohol spectrum disorders. Community Ment Health J 2004; 40 (06) 499-511
  • 45 Paley B, O’Connor MJ. Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management. Dev Disabil Res Rev 2009; 15 (03) 258-267
  • 46 Mansfield M. Accomodating The Fetal Alcohol Spectrum Disorders In The Diagnostic And Statistical Manual Of Mental Disorders (DSM V). J FAS Int 2006; 4: 1-10