Adenosindiphosphat (ADP)-induzierte Plättchenaktivierung
spielt eine entscheidende Rolle bei der Bildung des thrombotischen
Gefäßverschlusses und der Pathogenese der koronaren Herzerkrankung.
Die duale Thrombozytenaggregationshemmung mit den ADP-Rezeptor-Antagonisten
wie Clopidogrel in Kombination mit Aspirin gilt inzwischen als Standardtherapie
nach erfolgter Stentimplantation. Der vorliegende Beitrag gibt eine Übersicht über
die aktuellen Entwicklungen auf dem Gebiet der ADP-Rezeptor-Antagonisten.
Abstract
Adenosine diphosphate (ADP)-induced platelet activation plays
a pivotal role in the thrombocyte aggregation and pathogenesis of
ischemic heart disease. The long-term benefit of dual anti-platelet
therapy with ADP-receptor antagonists, such as clopidogrel, in combination
with aspirin is well established for patients following coronary stent
implantation. This review discusses latest developments in the field
of ADP-receptor antagonists.
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