Exp Clin Endocrinol Diabetes 2011; 119(10): 618-620
DOI: 10.1055/s-0031-1280799
Short Communication
© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New York

Pancreatic Autoantibodies, HLA DR and PTPN22 Polymorphisms in First Degree Relatives of Patients with Type 1 Diabetes and Multiethnic Background

B. Barone
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
J. R. Dantas
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
M. H. Almeida
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
B. S. Anna-Gomes
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
M.D. R. Bencke-Gongalves
2   Nuclear Medicine Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
M. S. Albernaz
2   Nuclear Medicine Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
M. R. Rodrigues
2   Nuclear Medicine Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
L. Zajdenverg
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
R. Kupfer
3   Diabetes Section, Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE), Rio de Janeiro/RJ, Brazil
,
A. Milech
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
M. Rodacki
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
,
J.E. P. Oliveira
1   Nutrology Section, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro/RJ, Brazil
› Author Affiliations
Further Information

Publication History

received 21 January 2011
first decision 09 April 2011

accepted 31 May 2011

Publication Date:
08 November 2011 (online)

Abstract

Aim:

To evaluate the prevalence of pancreatic auto-antibodies (PAb) as well as its relationship with HLA DR B1 and PTPN22 polymorphisms in first degree relatives (FDR) of Brazilian patients with Type 1 diabetes (T1D) and multiethnic background.

Methods:

FDR of patients with T1D were interviewed and blood was sampled for PAb measurement, HLA DRB1 and PTPN22 genotyping. Genotyping was also performed in index cases.

Results:

In FDR (n=78), 16.7% presented at least one PAb. These individuals had a higher prevalence of HLA DRB1* 03 than others (p=0.03), without differences in PTPN22 genotyping. While the genetic profile was similar in FDR with PAb and their index cases, those without PAb had a lower frequency of HLA DR B1 * 03 than their correspondent patients (p=0.009).

Conclusion:

In this multiethnic population, a significant proportion of FDR of T1D patients had PAb, which was associated with HLA DR B1 * 03 but not with the PTPN22 polymorphism.

Type 1 diabetes and relatives: Antibodies, genetics

 
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