RSS-Feed abonnieren
DOI: 10.1055/s-0031-1280670
Radioembolization for Hepatocellular Carcinoma Complicated by Biliary Stricture
Publikationsverlauf
Publikationsdatum:
16. Juni 2011 (online)
ABSTRACT
The authors present a case of radiation-induced biliary stricture following yttrium-90 (90Y) radioembolization for hepatocellular carcinoma. Biliary complications (e.g., biliary stricture, biliary necrosis, biloma) following radioembolization and other locoregional therapies are uncommon and usually managed conservatively. In instances when biliary injury is refractory to medical management, as in the case presented herein, endoscopic, percutaneous, or surgical intervention may be required. Timely diagnosis of biliary complications with correlation to liver function permits optimal clinical management of patients undergoing 90Y radioembolization.
KEYWORDS
Radioembolization - hepatocellular carcinoma - complications - biliary stricture
REFERENCES
- 1 Salem R, Thurston K G. Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: Technical and methodologic considerations. J Vasc Interv Radiol. 2006; 17 (8) 1251-1278
- 2 National Cancer Institute .Common Toxicity Criteria for Adverse Events v3.0 Available at: http://ctep.cancer.gov/forms/CTCAEv3.pdf Accessed November 15, 2010
- 3 Atassi B, Bangash A K, Lewandowski R J et al.. Biliary sequelae following radioembolization with Yttrium-90 microspheres. J Vasc Interv Radiol. 2008; 19 (5) 691-697
- 4 Ibrahim S M, Nikolaidis P, Miller F H et al.. Radiologic findings following Y90 radioembolization for primary liver malignancies. Abdom Imaging. 2009; 34 (5) 566-581
- 5 Salem R, Thurston K G. Radioembolization with 90yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 2: special topics. J Vasc Interv Radiol. 2006; 17 (9) 1425-1439
- 6 Yip D, Allen R, Ashton C, Jain S. Radiation-induced ulceration of the stomach secondary to hepatic embolization with radioactive yttrium microspheres in the treatment of metastatic colon cancer. J Gastroenterol Hepatol. 2004; 19 (3) 347-349
- 7 Sakamoto I, Iwanaga S, Nagaoki K et al.. Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization. AJR Am J Roentgenol. 2003; 181 (1) 79-87
- 8 Kim H K, Chung Y H, Song B C et al.. Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. J Clin Gastroenterol. 2001; 32 (5) 423-427
- 9 Wood T F, Rose D M, Chung M, Allegra D P, Foshag L J, Bilchik A J. Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol. 2000; 7 (8) 593-600
- 10 Akahane M, Koga H, Kato N et al.. Complications of percutaneous radiofrequency ablation for hepato-cellular carcinoma: imaging spectrum and management. Radiographics. 2005; 25 (Suppl 1) S57-S68
- 11 Kim S H, Lim H K, Choi D et al.. Changes in bile ducts after radiofrequency ablation of hepatocellular carcinoma: frequency and clinical significance. AJR Am J Roentgenol. 2004; 183 (6) 1611-1617
- 12 Cherqui D, Palazzo L, Piedbois P et al.. Common bile duct stricture as a late complication of upper abdominal radiotherapy. J Hepatol. 1994; 20 (6) 693-697
- 13 Nakakubo Y, Kondo S, Katoh H, Shimizu M. Biliary stricture as a possible late complication of radiation therapy. Hepatogastroenterology. 2000; 47 (36) 1531-1532
- 14 Salem R, Thurston K G. Radioembolization with yttrium-90 microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies: part 3: comprehensive literature review and future direction. J Vasc Interv Radiol. 2006; 17 (10) 1571-1593
Jeet MinochaM.D.
Department of Radiology, Northwestern University Feinberg School of Medicine
676 North St Clair Street, Suite 800, Chicago, IL 60611-2927
eMail: jeetminocha@gmail.com