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DOI: 10.1055/s-0031-1279984
© Georg Thieme Verlag KG Stuttgart · New York
Carlina Oxide – A Natural Polyacetylene from Carlina acaulis (Asteraceae) with Potent Antitrypanosomal and Antimicrobial Properties
Publikationsverlauf
received March 3, 2011
revised May 19, 2011
accepted May 21, 2011
Publikationsdatum:
15. Juni 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201117/lookinside/thumbnails/10.1055-s-0031-1279984-1.jpg)
Abstract
Carlina acaulis (Asteraceae) has a long history of medicinal use in Europe due to its antimicrobial properties. The strong activity of Carlina oxide, the main compound of the essential oil of C. acaulis against two MRSA strains, Streptococcus pyogenes, Pseudomonas aeruginosa, Candida albicans, and C. glabrata was confirmed. A strong and selective activity against Trypanosoma brucei brucei with an IC50 of 1.0 µg/mL and a SI of 446 compared to human HeLa cells was recorded. The selective toxicity of Carlina oxide makes it a promising lead compound for the development of drugs to treat African trypanosomiasis and multiresistant gram-positive bacteria.
Key words
Carlina acaulis - Asteraceae - Carlina oxide - Trypanosoma brucei brucei – MRSA - cytotoxicity
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Prof. Dr. Michael Wink
Institute of Pharmacy and Molecular Biotechnology
Heidelberg University
Im Neuenheimer Feld 364
69120 Heidelberg
Germany
Telefon: +49 62 21 54 48 80
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