Klin Monbl Augenheilkd 2011; 228(4): 366-367
DOI: 10.1055/s-0031-1273264
Der interessante Fall

© Georg Thieme Verlag KG Stuttgart · New York

Vitreous Infiltration in Chronic Myelogenous Leukaemia

Glaskörperinfiltration bei chronischer myeloischer LeukämieL. Konstantinidis, A. Bissig, F. Gindroz, E. Bovey, A. Schalenbourg
Weitere Informationen

Publikationsverlauf





Publikationsdatum:
11. April 2011 (online)

Background

Leukaemia is a neoplasm of the hematopoietic system: it is classified by the lineage and differentiation of the malignant cell. Ocular involvement is common in leukaemia patients and results either from direct leukemic infiltration or from secondary haematological abnormalities such as anaemia, thrombocytopenia, hyperviscosity, and immunosuppression [1]. Leukemic infiltration affects usually the choroid and the retina [2]. However, vitreous infiltration is extremely rare: only a few cases in acute leukaemia have been reported [2] [3] [4] [5] [6] [7] and, as far as we are aware, only one case in chronic myelogenous leukaemia [8].

We present a case of chronic myelogenous leukaemia associated with extensive vitreous infiltration.

References

  • 1 Gordon K B, Rugo H S, Duncan J L et al. Ocular manifestations of leukemia: leukemic infiltration versus infectious process.  Ophthalmology. 2001;  108 2293-2300
  • 2 Kincaid M C, Green W R. Ocular and orbital involvement in leukemia.  Surv Ophthalmol. 1983;  27 211-232
  • 3 Newman N M, Smith M E, Gay A J. An unusual case of leukemia involving the eye: a clinico-pathological study.  Surv Ophthalmol. 1972;  16 316-321
  • 4 Swartz M, Schumann G B. Acute leukemic infiltration of the vitreous diagnosed by pars plana aspiration.  Am J Ophthalmol. 1980;  90 326-330
  • 5 Zhioua R, Boussen I, Malek I et al. Acute lymphoblastic leukemia and vitreous infiltration. A case study.  J Fr Ophtalmol. 2001;  24 180-182
  • 6 De Juan E, Green W R, Rice T A et al. Optic disc neovascularization associated with ocular involvement in acute lymphocytic leukemia.  Retina. 1982;  2 61-64
  • 7 Hirata A, Miyazaki T, Tanihara H. Intraocular infiltration of adult T-cell leukemia.  Am J Ophthalmol. 2002;  134 616-618
  • 8 Pleyer U, Weidle E G, Richter U et al. Isolated infiltration of the vitreous body as a sign of blast crisis in chronic myeloid leukemia.  Fortschr Ophthalmol. 1990;  87 554-556
  • 9 Reese A, Guy I. Exophthalmos in leukemia.  Am J Ophthalmol. 1933;  16 718
  • 10 Kuwabara T. Leukemic Miliary Nodules In The Retina.  Arch Ophthalmol. 1964;  72 494-497

Lazaros Konstantinidis, MD

Jules-Gonin Eye Hospital

Av. de France 15

1004 Lausanne

Switzerland

Telefon: ++ 41/21/6 26 81 11

eMail: konstantinidis@me.com