Dtsch Med Wochenschr 2011; 136(8): 371-375
DOI: 10.1055/s-0031-1272538
Übersicht | Review article
Gastroenterologie, Ernährungsmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Probiotische Behandlung des Reizdarmsyndroms

Probiotic therapy of the irritable bowel syndromeP. Enck1 , S. Klosterhalfen1 , 2 , U. Martens1
  • 1Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Tübingen
  • 2Institut für klinische Neurowissenschaften und Medizinische Psychologie, Heinrich-Heine-Universität, Düsseldorf
Further Information

Publication History

eingereicht: 8.10.2010

akzeptiert: 13.1.2011

Publication Date:
17 February 2011 (online)

Zusammenfassung

Das Reizdarmsyndrom (RDS) zählt zu den häufigsten gastroenterologischen Krankheitsbildern mit einer Prävalenz in Deutschland von ca. 12 %, charakterisiert durch abdominelle Schmerzen oder Beschwerden, veränderte Stuhlfrequenz und -konsistenz, Meteorismus und Blähungen. Zwischen den verschiedenen Fachdisziplinen, die Patienten mit RDS sehen und behandeln (Hausärzte, Gastroenterologen, Psychosomatiker) besteht bislang keine Einigkeit über die klinische Definition. Metaanalysen von Therapiestudien beim RDS belegen den hohen Stellenwert der Probiotika bei diesem Krankheitsbild, insbesondere nachdem neuere Medikamentenentwicklungen den Markt nicht erreicht haben oder wieder vom Markt genommen worden sind. Neben der weltweiten aktuellen Studienlage zur Wirksamkeit von Probiotika auf Symptome des Reizdarmsyndroms werden hier drei klinische Studien aus Deutschland mit E.coli-Präparaten vorgestellt, die deren Wirksamkeit beim RDS im Kindes- und im Erwachsenenalter belegen.

Abstract

The irritable bowel syndrome (IBS) is among the most common disorders in gastroenterological practice with a prevalence of approx. 12 % in Germany, and it is characterized by abdominal pain or discomfort, altered stool frequency and consistency, and meteorism and bloating. There is currently no agreement between those seeing patients with IBS (general practitioner, gastroenterologist, psychosomatics) on the criteria for clinical diagnosis. Metaanalyses of treatment studies in IBS have shown that probiotics have a high clinical efficacy in IBS, especially since development of novel pharmaceutical compounds have not reached the market or have been withdrawn. In addition to the actual status of probiotic efficacy in IBS studies conducted worldwide, we present 3 German clinical studies with probiotic E.coli preparations that have proven their efficacy in IBS in adults and in children.

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Prof. Dr. Paul Enck

Klinik für Psychosomatische Medizin und Psychotherapie
Universitätsklinikum Tübingen

Frondsbergstr 23

72076 Tübingen

Phone: 07071/2989118

Fax: 07071/294382

Email: Paul.Enck@uni-tuebingen.de