Semin Reprod Med 2011; 29(2): 124-129
DOI: 10.1055/s-0031-1272474
© Thieme Medical Publishers

Surgical Management of Pain and Infertility Secondary to Endometriosis

Gouri B. Diwadkar1 , Tommaso Falcone1
  • 1Department of Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio
Further Information

Publication History

Publication Date:
24 March 2011 (online)

ABSTRACT

The management of pain and infertility secondary to endometriosis remains a challenge. Surgical management of early-stage endometriosis-associated infertility has only a mild effect with a number needed to treat of at least 12 to achieve one pregnancy. Excision of endometriomas provides the best outcome for fertility and pain; however, there is a potential to reduce the ovarian reserve. Pain relief is seen in most patients undergoing surgical management but with a high recurrence rate over time. Long-term postoperative medical suppressive therapy with oral contraceptives may have some benefit in reducing recurrence of symptoms. Hysterectomy is effective in the long-term management of chronic pain associated with endometriosis.

REFERENCES

  • 1 Ballard K D, Seaman H E, de Vries C S, Wright J T. Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study—Part 1.  BJOG. 2008;  115 (11) 1382-1391
  • 2 Sutton C J, Pooley A S, Ewen S P, Haines P. Follow-up report on a randomized controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal to moderate endometriosis.  Fertil Steril. 1997;  68 (6) 1070-1074
  • 3 Johnson N P, Farquhar C M, Crossley S et al. A double-blind randomised controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain.  BJOG. 2004;  111 (9) 950-959
  • 4 Vercellini P, Aimi G, Busacca M, Apolone G, Uglietti A, Crosignani P G. Laparoscopic uterosacral ligament resection for dysmenorrhea associated with endometriosis: results of a randomized, controlled trial.  Fertil Steril. 2003;  80 (2) 310-319
  • 5 Daniels J, Gray R, Hills R K LUNA Trial Collaboration et al. Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial.  JAMA. 2009;  302 (9) 955-961
  • 6 Abbott J, Hawe J, Hunter D, Holmes M, Finn P, Garry R. Laparoscopic excision of endometriosis: a randomized, placebo-controlled trial.  Fertil Steril. 2004;  82 (4) 878-884
  • 7 Abbott J A, Hawe J, Clayton R D, Garry R. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2-5 year follow-up.  Hum Reprod. 2003;  18 (9) 1922-1927
  • 8 Wright J, Lotfallah H, Jones K, Lovell D. A randomized trial of excision versus ablation for mild endometriosis.  Fertil Steril. 2005;  83 (6) 1830-1836
  • 9 Cheong Y, Tay P, Luk F, Gan H C, Li T C, Cooke I. Laparoscopic surgery for endometriosis: how often do we need to re-operate?.  J Obstet Gynaecol. 2008;  28 (1) 82-85
  • 10 Weir E, Mustard C, Cohen M, Kung R. Endometriosis: what is the risk of hospital admission, readmission, and major surgical intervention?.  J Minim Invasive Gynecol. 2005;  12 (6) 486-493
  • 11 Shakiba K, Bena J F, McGill K M, Minger J, Falcone T. Surgical treatment of endometriosis: a 7-year follow-up on the requirement for further surgery.  Obstet Gynecol. 2008;  111 (6) 1285-1292
  • 12 Vercellini P, Pietropaolo G, De Giorgi O, Daguati R, Pasin R, Crosignani P G. Reproductive performance in infertile women with rectovaginal endometriosis: is surgery worthwhile?.  Am J Obstet Gynecol. 2006;  195 (5) 1303-1310
  • 13 Vercellini P, Crosignani P G, Abbiati A, Somigliana E, Viganò P, Fedele L. The effect of surgery for symptomatic endometriosis: the other side of the story.  Hum Reprod Update. 2009;  15 (2) 177-188
  • 14 Seracchioli R, Mabrouk M, Manuzzi L et al. Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis.  Hum Reprod. 2009;  24 (11) 2729-2735
  • 15 Vercellini P, Somigliana E, Daguati R, Vigano P, Meroni F, Crosignani P G. Postoperative oral contraceptive exposure and risk of endometrioma recurrence.  Am J Obstet Gynecol. 2008;  198 (5) 504.e1-e5
  • 16 Abou-Setta A M, Al-Inany H G, Farquhar C M. Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery.  Cochrane Database Syst Rev. 2006;  (4) CD005072
  • 17 Mansour G, Aziz N, Sharma R, Falcone T, Goldberg J, Agarwal A. The impact of peritoneal fluid from healthy women and from women with endometriosis on sperm DNA and its relationship to the sperm deformity index.  Fertil Steril. 2009;  92 (1) 61-67
  • 18 Lemos N A, Arbo E, Scalco R, Weiler E, Rosa V, Cunha-Filho J S. Decreased anti-Müllerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis.  Fertil Steril. 2008;  89 (5) 1064-1068
  • 19 Said T M, Agarwal A, Falcone T, Sharma R K, Bedaiwy M A, Li L. Infliximab may reverse the toxic effects induced by tumor necrosis factor alpha in human spermatozoa: an in vitro model.  Fertil Steril. 2005;  83 (6) 1665-1673
  • 20 Marcoux S, Maheux R, Bérubé S. Canadian Collaborative Group on Endometriosis . Laparoscopic surgery in infertile women with minimal or mild endometriosis.  N Engl J Med. 1997;  337 (4) 217-222
  • 21 Parazzini F. Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell'Endometriosi.  Hum Reprod. 1999;  14 (5) 1332-1334
  • 22 Vercellini P, Somigliana E, Viganò P, Abbiati A, Barbara G, Crosignani P G. Surgery for endometriosis-associated infertility: a pragmatic approach.  Hum Reprod. 2009;  24 (2) 254-269
  • 23 Busacca M, Somigliana E, Bianchi S et al. Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III-IV: a randomized controlled trial.  Hum Reprod. 2001;  16 (11) 2399-2402
  • 24 Pagidas K, Falcone T, Hemmings R, Miron P. Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer.  Fertil Steril. 1996;  65 (4) 791-795
  • 25 Vercellini P, Somigliana E, Viganò P, De Matteis S, Barbara G, Fedele L. The effect of second-line surgery on reproductive performance of women with recurrent endometriosis: a systematic review.  Acta Obstet Gynecol Scand. 2009;  88 (10) 1074-1082
  • 26 Hart R J, Hickey M, Maouris P, Buckett W. Excisional surgery versus ablative surgery for ovarian endometriomata.  Cochrane Database Syst Rev. 2008;  (2) CD004992
  • 27 Beretta P, Franchi M, Ghezzi F, Busacca M, Zupi E, Bolis P. Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation.  Fertil Steril. 1998;  70 (6) 1176-1180
  • 28 Alborzi S, Momtahan M, Parsanezhad M E, Dehbashi S, Zolghadri J, Alborzi S. A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas.  Fertil Steril. 2004;  82 (6) 1633-1637
  • 29 Alborzi S, Ravanbakhsh R, Parsanezhad M E, Alborzi M, Alborzi S, Dehbashi S. A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma.  Fertil Steril. 2007;  88 (2) 507-509
  • 30 Somigliana E, Vercellini P, Viganó P, Ragni G, Crosignani P G. Should endometriomas be treated before IVF-ICSI cycles?.  Hum Reprod Update. 2006;  12 (1) 57-64
  • 31 Bedaiwy M A, Falcone T, Katz E, Goldberg J M, Assad R, Thornton J. Association between time from endometriosis surgery and outcome of in vitro fertilization cycles.  J Reprod Med. 2008;  53 (3) 161-165
  • 32 Daraï E, Marpeau O, Thomassin I, Dubernard G, Barranger E, Bazot M. Fertility after laparoscopic colorectal resection for endometriosis: preliminary results.  Fertil Steril. 2005;  84 (4) 945-950
  • 33 Ferrero S, Anserini P, Abbamonte L H, Ragni N, Camerini G, Remorgida V. Fertility after bowel resection for endometriosis.  Fertil Steril. 2009;  92 (1) 41-46
  • 34 Brouwer R, Woods R J. Rectal endometriosis: results of radical excision and review of published work.  ANZ J Surg. 2007;  77 (7) 562-571
  • 35 Pellicano M, Bramante S, Guida M et al. Ovarian endometrioma: postoperative adhesions following bipolar coagulation and suture.  Fertil Steril. 2008;  89 (4) 796-799
  • 36 Brown C B, Luciano A A, Martin D, Peers E, Scrimgeour A, diZerega G S. Adept Adhesion Reduction Study Group . Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study.  Fertil Steril. 2007;  88 (5) 1413-1426

Tommaso FalconeM.D. 

Department of Obstetrics and Gynecology, Desk A-81, Cleveland Clinic

9500 Euclid Avenue, Cleveland, OH 44195

Email: FALCONT@CCF.ORG