Die Existenz der NICO wird heute in der Main-Stream-Zahnheilkunde weitestgehend verkannt. Der Grund hierfür ist, dass das normale Röntgenbild die im Songiosaraum ablaufenden NICO-Prozesse nicht zeigt. Der Autor vergleicht daher bei mehreren klinischen Fällen Röntgenbilder und andere bildgebende Verfahren mit einem computergestützten Ultraschall-Verfahren namens CAVITAT, das in der Aufdeckung osteolytischer NICO-Areale überlegen scheint. Unter einem systemischen Aspekt der Zahnmedizin untersucht der Autor NICO-Proben unter dem Gesichtspunkt erhöhter Immunbotenstoffe mit dem Ergebnis hoher RANTES-Spiegel. Diese sind ein Hinweis für entzündliche Aktivitäten und NICO kann daher als systemisch entzündungsförderndes Geschehen betrachtet werden.
The existence of NICO is largely denied today in main stream dentistry. The reason is that normal X-ray do not show the process of bone marrow osteolytic NICO. The author compares in several clinical cases X-rays and other radiographic imaging with a computer-assisted through-transmission alveolar sonography called CAVITAT, which proves superior to radiology for the detection of osteolytic NICO. Under a systemic aspect in dentistry the author is targeting NICO as a possible source of inflammatory immune messengers, with the striking outcome of high levels of RANTES. It is regarded that raised RANTES is a proof for inflammatory activity and NICO can be defined as sort of systemic inflammatory focus.
Schlüsselwörter
Röntgenbild - NICO - bildgebende Verfahren - Ultraschall-Verfahren - Immunbotenstoffe - RANTES - systemisch entzündungsfördernd
Key words
X-ray - Radiographic Imaging - Immune Messengers - RANTES - NICO - Systemic Inflammatory Focus
Literatur
-
1
Bolin LM et al..
Primary sensory neurons migrate in response to the chemokine RANTES.
J Neuroimmunol.
1998;
81
49-57
-
2
Bouquot JE, Christian J.
Longterm effects of jawbone curettage on the pain of facial neuralgia.
J Oral Maxillofac Surg.
1995;
53
387-397
-
3
Bouquot J, Martin W, Wrobleski G.
Computer-based thru-transmission sonography (CTS) imaging of ischemic osteonecrosis of the jaws – a preliminary investigation of 6 cadaverjaws and 15 pain patients.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2001;
92
550
-
4
Bouquot JE, Roberts AM, Person P et al..
NICO (neuralgia-inducing cavitational osteonecrosis): Osteomyelitis in 224 jawbone samples from patients with facial neuralgias.
Oral Surg Oral Med Oral Pathol.
1992;
73
307-319
-
5
Bouquot JE.
Neuralgia-inducing cavitational osteonecrosis (NICO).
Oral Surg Oral Med Oral Pathol.
1992;
73
307-319
-
6 Bouquot JE, Shankland II WE, Margolis M et al.. Through-transmission alveolar ultrasonography (TAU) – new technology for detection of Iow bone density of the jaws. Comparison with radiology for 92 osteoporotic alveolar sites with histopathologic confirmation. Proceedings, annual meeting, American Academy of Oral & Maxillofacial Pathology, New Orleans, April. 2002
-
7
Bouquot JE, Shankland II WE, Margolis M.
Through-transmission alveolar ultrasonography (TAU) – new technology for evaluation of bone density and desiccation. Comparison with radiology of 170 biopsied alveolar sites of osteoporotic and ischemic disease.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2002;
93
-
8
Bumann A.
Der aktuelle Stand bildgebender Verfahren.
Wissenschaft und Fortbildung BZB.
2009;
11
59-63
-
9
Radhika Andavolu Gade.
Rantes: a genetic riskmarker for multiple sclerosis. Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst 308, 39000 Bob Hope Dr, Rancho Mirage, CA 92270, USA.
Mult Scler.
-
10 Gleditsch J. Mundakupunktur: Ein Schlüssel zum Verständnis regulativer Funktionssysteme. München: Urban & Fischer; 2005
-
11
Hirano F et al..
Thrombin-induced expression of RANTES mRNA through protease activated receptor-1 in human synovial fibroblasts.
Ann Rheum Dis.
2002;
61
834-837
-
12
Karnoub AE, Dash AB, Vo AP et al..
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.
Nature.
2007;
449
557-563
-
13
Kimura Y et al..
Mast cells and T cells in Kimura's disease express increased levels of interleukin-4, interleukin-5, eotaxin and RANTES.
Clin Exp Allergy.
2002;
32
1787-1793
-
14
Lechner J.
Gesichtsschmerz aus zahnärztlicher Sicht – Eine Replik.
ZWR.
2009;
118
32-38
-
15 Lechner J. Störfelder im Trigeminusbereich und Systemerkrankungen: Ein systemisches Sanierungskonzept für Zahn-Störfelder. Bad Kötzting: Verlag für Ganzheitliche Medizin; 1999
-
16 Lechner J. Chronische Kieferostitis und Systemerkrankung. Biologische Zahnmedizin. Heidelberg: Hüthig-Verlag; 1990
-
17 Lechner J. Herd, Regulation und Information – Störfelder im Zahn-, Mund- und Kieferbereich. Auflage. Heidelberg: HAUG Verlag; 1998. 2
-
18
Lechner J, Mayer W.
Immune messengers in Neuralgia Inducing Cavitational Osteonecrosis (NICO) in jaw bone and systemic interference.
European Journal of Integrative Medicine.
2010;
2
71-77
-
19
Mrowietz U et al..
The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice.
Br J Cancer.
1999;
79
1025-1031
-
20
Rathanaswami P et al..
Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokines.
J Biol Chem.
1993;
268
5834-5839
-
21
Ratner EJ, Langer B, Evins ML.
Alveolar CAVITATional osteopathosis -- manifestations of an infectious process and its implication in the causation of chronic pain.
J Periodontol.
1986;
57
593-603
-
22
Shankland WE.
OsteoCAVITATional lesions (Ratner bone cavities): frequently misdiagnosed as trigeminal neuralgia-a case report.
J Craniomand Pract.
1993;
11
232-234
-
23
Shankland WE, Jiao X, Meng Q.
The influence of pathologic bone cavity of jaw bone on the etiopathology of trigeminal neuralgia.
Acta Acad Med Sichuan.
1981;
12
243-247
-
24
Shankland WE.
Medullary and Odontogenic Disease in the Painful Jaw: Clinicopathologic Review of 500 Consecutive Lesions.
J Craniomandibular Pract.
2002;
20
295-303
-
25
Wang E et al..
Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.
Cancer Res.
2002;
62
3581-3586
-
26
Wang M, Jiao X, Meng Q et al..
Localization method in the diagnosis of the pathological jaw bone cavity.
I Acta Acad Med Sichuan.
1982;
13
341-344
-
27
Zhang N et al..
Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons.
J Immunol.
2004;
173
594-599
Korrespondenzadresse
Dr. J Lechner
Grünwalder Str. 10A
81547 München
eMail: drlechner@aol.com
