A sense of time: body clocks, sleep and health

Einleitung

Unser Leben wird von unserer inneren Uhr bestimmt. Diese biologische Uhr beeinflusst unter anderem unser Schlafverhalten, unsere Stimmung und unsere körperliche Verfassung. Dass die Tageszeit auch medizinische Parameter beeinflusst, zeigt sich z. B. bei der Messung von Blutdruck und Körpertemperatur: Am Tag und in der Nacht variieren die Werte. Bekannt ist außerdem, dass auch der Hormonhaushalt von der Tages- und Nachtzeit abhängt. Diese Variationen beeinflussen unser Verhalten und unseren Gesundheitszustand. Die Chronobiologie ist daher ein wichtiger Forschungsbereich für Mediziner und hat in den letzten Jahren mehr und mehr an Bedeutung gewonnen.

References

• 1 Achermann P, Borbely A A. Low-frequency (< 1 Hz) oscillations in the human sleep electroencephalogram.  Neuroscience. 1997;  81 213-222
• 2 Aschoff J. Freerunning and entrained circadian rhythms. In: Aschoff J, ed Handbook of Behavioral Neurobiology: Biological Rhythms. New York: Plenum Press; 1981: 81-94
• 3 Aston-Jones G, Smith R J, Moorman D E, Richardson K A. Role of lateral hypothalamic orexin neurons in reward processing and addiction.  Neuropharmacology. 2008; 56: 112–121; 
• 4 Barnes R G, Forbes M J, Arendt J. Shift type and season affect adaptation of the 6-sulphatoxymelatonin rhythm in offshore oil rig workers.  Neurosci Lett. 1998;  252 179-182
• 5 Basheer R, Strecker R E, Thakkar M M, McCarley R W. Adenosine and sleep-wake regulation.  Prog Neurobiol. 2004;  73 379-396
• 6 Boutrel B, Koob G F. What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.  Sleep. 2004;  27 1181-1194
• 7 Brower K J. Insomnia, alcoholism and relapse.  Sleep Med Rev. 2003;  7 523-539
• 8 Caldwell J A, Caldwell J L, Smith J K, Brown D L. Modafinil’s effects on simulator performance and mood in pilots during 37 h without sleep.  Aviat Space Environ Med. 2004;  75 777-784
• 9 Carrier J, Monk T H. Circadian rhythms of performance: new trends.  Chronobiol Int. 2000;  17 719-732
• 10 Cohen R A, Albers H E. Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: a case study.  Neurology. 1991;  41 726-729
• 11 Costa G. Guidelines for the medical surveillance of shift workers.  Scand J Work Environ Health. 1998;  24 Suppl 3 151-155
• 12 Crowley S J, Lee C, Tseng C Y, Fogg L F, Eastman C I. Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work.  Sleep. 2004;  27 1077-1087
• 13 Czeisler C A, Johnson M P, Duffy J F. et al . Exposure to bright light and darkness to treat physiologic maladaptation to night work.  N Engl J Med. 1990;  322 1253-1259
• 14 Davis S, Mirick D K, Stevens R G. Night shift work, light at night, and risk of breast cancer.  J Natl Cancer Inst. 2001;  93 1557-1562
• 15 Deacon S, Arendt J. Adapting to phase shifts, I. An experimental model for jet lag and shift work.  Physiol Behav. 1996a;  59 665-673
• 16 Deacon S, Arendt J. Adapting to phase shifts, II. Effects of melatonin and conflicting light treatment.  Physiol Behav. 1996b; 
• 17 Drummond S P, Brown G G. The effects of total sleep deprivation on cerebral responses to cognitive performance.  Neuropsychopharmacology. 2001;  25 S68-73
• 18 Drummond S P, Brown G G, Salamat J S, Gillin J C. Increasing task difficulty facilitates the cerebral compensatory response to total sleep deprivation.  Sleep. 2004;  27 445-451
• 19 Ebisawa T. Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes.  J Pharmacol Sci. 2007;  103 150-154
• 20 Evarson C A. Sustained sleep deprivation impairs host defense.  Am J Physiol. 1993;  265 R1148-R1154
• 21 Fava M. Daytime sleepiness and insomnia as correlates of depression.  J Clin Psychiatry. 2004;  65, Suppl 16 27-32
• 22 Foster R G, Hankins M W. Circadian vision.  Curr Biol. 2007;  17 R746-751
• 23 Foster R G, Kreitzman L. Rhythms of Life: The biological clocks that control the daily lives of every living thing. London: Profile Books; 2004
• 24 Foster R G, Wulff K. The rhythm of rest and excess.  Nat Rev Neurosci. 2005;  6 407-414
• 25 Fujii S, Ji Z, Morita N, Sumikawa K. Acute and chronic nicotine exposure differentially facilitate the induction of LTP.  Brain Res. 1999;  846 137-143
• 26 Gais S, Plihal W, Wagner U, Born J. Early sleep triggers memory for early visual discrimination skills.  Nat Neurosci. 2000;  3 1335-1339
• 27 Hansen J. Increased breast cancer risk among women who work predominantly at night.  Epidemiology. 2001;  12 74-77
• 28 Harrington J M. Health effects of shift work and extended hours of work.  Occup Environ Med. 2001;  58 68-72
• 29 Horne J, Reyner L. Vehicle accidents related to sleep: a review.  Occup Environ Med. 1999;  56 289-294
• 30 Irwin M, McClintick J, Costlow C. et al . Partial night sleep deprivation reduces natural killer and cellular immune responses in humans.  FASEB J. 1996;  10 643-653
• 31 Johnson E O, Roehrs T, Roth T, Breslau N. Epidemiology of alcohol and medication as aids to sleep in early adulthood.  Sleep. 1998;  21 178-186
• 32 Karni A, Tanne D, Rubenstein B S, Askenasy J J, Sagi D. Dependence on REM sleep of overnight improvement of a perceptual skill.  Science. 1994;  265 679-682
• 33 Kreitzman L. The 24 Hour Society. London: Profile Books Ltd; 1999
• 34 Kryger M H. Diagnosis and management of sleep apnea syndrome.  Clin Cornerstone. 2000;  2 39-47
• 35 Landolt H P. Sleep homeostasis: a role for adenosine in humans?.  Biochem Pharmacol. 2008;  75 2070-2079
• 36 Leger D, Guilleminault C, Dreyfus J P, Delahaye C, Paillard M. Prevalence of insomnia in a survey of 12,778 adults in France.  J Sleep Res. 2000;  9 35-42
• 37 Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elevation of cortisol levels the next evening.  Sleep. 1997;  10 865-870
• 38 Levin E D, Simon B B. Nicotinic acetylcholine involvement in cognitive function in animals.  Psychopharmacol. 1998;  138 217-230
• 39 Lyons T J, French J. Modafinil: the unique properties of a new stimulant.  Aviat Space Environ Med. 1991;  62 432-435
• 40 Majde J A, Krueger J M. Neuroimmunology of sleep. In: D’haenen H, den Boer JA, Willner P, eds Biological Psychiatry. New York: Wiley; 2002: 1-11
• 41 Martin P. Counting Sheep. London: HarperCollins; 2002
• 42 Millar-Craig M W, Bishop C N, Raftery E B. Circadian variation of blood-pressure.  Lancet. 1978;  1 795-797
• 43 Nierenberg A A, Keefe B R, Leslie V C. et al . Residual symptoms in depressed patients who respond acutely to fluoxetine.  J Clin Psychiatry. 1999;  60 221-225
• 44 Nofzinger E A, Buysse D J, Germain A, Price J C, Miewald J M, Kupfer D J. Functional neuroimaging evidence for hyperarousal in insomnia.  Am J Psychiatry. 2004;  161 2126-2128
• 45 Ohayon M M. Epidemiology of insomnia: what we know and what we still need to learn.  Sleep Med Rev. 2002;  6 97-111
• 46 Ohayon M M, Roth T. Place of chronic insomnia in the course of depressive and anxiety disorders.  J Psychiatr Res. 2003;  37 9-15
• 47 Palmer C D, Harrison G A, Hiorns R W. Association between smoking and drinking and sleep duration.  Ann Hum Biol. 1980;  7 103-107
• 48 Parkin C, Fairweather D B, Shamsi Z, Stanley N, Hindmarch I. The effects of cigarette smoking on overnight performance.  Psychopharmacology (Berl). 1998;  136 172-178
• 49 Pasch S K. Disorders of thought, mood, and memory. In: Porth CM, Pathophysiology: Concepts of Altered Health 2004. Lippincott Williams & Wilkin; 2004: 1265-1287
• 50 Paykel E S, Ramana R, Cooper Z, Hayhurst H, Kerr J, Barocka A. Residual symptoms after partial remission: an important outcome in depression.  Psychol Med. 1995;  25 1171-1180
• 51 Phillips B A, Danner F J. Cigarette smoking and sleep disturbance.  Arch Intern Med. 1995;  155 734-737
• 52 Rajaratnam S M, Arendt J. Health in a 24-h society.  Lancet. 2001;  358 999-1005
• 53 Reid K J, Chang A M, Dubocovich M L, Turek F W, Takahashi J S, Zee P C. Familial advanced sleep phase syndrome.  Arch Neurol. 2001;  58 1089-1094
• 54 Riedel W J, Jolles J. Cognition enhancers in age-related cognitive decline.  Drugs Aging. 1996;  8 245-274
• 55 Roehrs T, Roth T. Sleep, sleepiness, sleep disorders and alcohol use and abuse.  Sleep Med Rev. 2001;  5 287-297
• 56 Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: daily temporal patterns of human chronotypes.  J Biol Rhythms. 2003;  18 80-90
• 57 Roth T W, Walsh J K. TAK in transient insomnia.  Sleep. 2003;  Abstr. Suppl 26
• 58 Salin-Pascual R J, Roehrs T A, Merlotti L A, Zorick F, Roth T. Long-term study of the sleep of insomnia patients with sleep state misperception and other insomnia patients.  Am J Psychiatry. 1992;  149 904-908
• 59 Schernhammer E S, Laden F, Speizer F E. et al . Night-shift work and risk of colorectal cancer in the nurses’ health study.  J Natl Cancer Inst. 2003;  95 825-828
• 60 Schwartz J R. Pharmacologic management of daytime sleepiness.  J Clin Psychiatry. 2004;  65, Suppl 16 46-49
• 61 Sephton S, Spiegel D. Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?.  Brain Behav Immun. 2003;  5 321-328
• 62 Smith C, Smith D. Ingestion of ethanol just prior to sleep onset impairs memory for procedural but not declarative tasks.  Sleep. 2003;  26 185-191
• 63 Smith M T, Perlis M L, Chengazi V U. et al . Neuroimaging of NREM sleep in primary insomnia: a Tc-99-HMPAO single photon emission computed tomography study.  Sleep. 2002;  25 325-335
• 64 Stewart K T, Hayes B C, Eastman C I. Light treatment for NASA shiftworkers.  Chronobiol Int. 1995;  12 141-151
• 65 Tononi G, Cirelli C. Sleep function and synaptic homeostasis.  Sleep Med Rev. 2006;  10 49-62
• 66 Trinkoff A M, Storr C L. Work schedule characteristics and substance use in nurses.  Am J Ind Med. 1998;  34 266-271
• 67 Tynes T, Hannevik M, Andersen A, Vistnes A I, Haldorsen T. Incidence of breast cancer in Norwegian female radio and telegraph operators.  Cancer Causes Control. 1996;  7 197-204
• 68 Uhlhaas P J, Singer W. Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology.  Neuron. 2006;  52 155-168
• 69 Van Dongen H P, Maislin G, Mullington J M, Dinges D F. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.  Sleep. 2003;  26 117-126
• 70 Vertes R P. Memory consolidation in sleep: Dream or reality.  Neuron. 2004;  44 135-148
• 71 Wagner U, Gais S, Haider H, Verleger R, Born J. Sleep inspires insight.  Nature. 2004;  427 352-355
• 72 Walker M P, Stickgold R. Sleep-dependent learning and memory consolidation.  Neuron. 2004;  44 121-133
• 73 Wedderburn A. Compressed working time.  Bulletin of European Studies on Time. 1996;  10
• 74 Whitehead D C, Thomas Jr H, Slapper D R. A rational approach to shift work in emergency medicine.  Ann Emerg Med. 1992;  21 1250-1258
• 75 Wigren H K, Schepens M, Matto V, Stenberg D, Porkka-Heiskanen T. Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep.  Neuroscience. 2007;  147 811-823
• 76 Wulff K, Gatti S, Wettstein J G, Foster R G. Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease.  Nature Reviews Neuroscience. 2010;  11 589-599
• 77 Zaidi F H, Hull J T, Peirson S N. et al . Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina.  Curr Bio. 2007;  17 2122-2128