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Orthopedic Trauma Directions 2010; 8(5): 31-37
DOI: 10.1055/s-0030-1267054
DOI: 10.1055/s-0030-1267054
Classic article review
© Georg Thieme Verlag KG Stuttgart · New York
Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures
The Journal of Bone and Joint Surgery American; 84-A (12): 2123 – 2134Further Information
Publication History
Publication Date:
09 November 2010 (online)
Author summary
Four hundred and fifty patients with an open tibial fracture were randomized to receive either intramedullary nail fixation and routine soft-tissue management only, or with the addition of an implant containing either 0.75 mg / mL or 1.50 mg / mL of recombinant human bone morphogenetic protein-2 (rhBMP-2). In this study, the use of 1.50 mg / mL of rhBMP significantly reduced the number and invasiveness of secondary procedures, accelerated fracture and wound healing, and reduced the rates of infection, hardware failure, and overall pain.