RSS-Feed abonnieren
DOI: 10.1055/s-0030-1262626
Gefäßchirurgie im Alter – Handlungsempfehlungen für die chirurgische Praxis
Vascular Surgery in the Elderly – Recommendations for Clinical PracticePublikationsverlauf
Publikationsdatum:
28. Januar 2011 (online)
Zusammenfassung
Durch die zunehmende Überalterung der Bevölkerung in den Industriestaaten nimmt nicht nur die Zahl der Gefäßerkrankungen stetig zu, sondern auch der Anteil an den sogenannten Betagten (> 80 Jahre), die aufgrund ihres hohen Risikoprofils sowohl aus anästhesiologischer als auch aus chirurgischer Sicht ein herausforderndes Patientenklientel bilden. Anhand eines Übersichtsartikels soll die evidenzbasierte gefäßchirurgische Indikationsstellung bei spezifischen Gefäßerkrankungen im Alter und der Einfluss des Alters auf den Therapieerfolg dargestellt werden. Basierend auf den derzeitigen Ergebnissen der Literatur, bezogen auf das Alter > 80 Jahre, werden Handlungsempfehlungen der 3 ausgewählten Erkrankungen (Karotisstenose, Bauchaortenaneurysma und pAVK) für die tägliche Praxis abgeleitet, die die Entscheidungsfindung hinsichtlich des Therapieverfahrens erleichtern sollen. Zusammenfassend stellt die CEA (Karotisendarterektomie) mit der höchstmöglichen Evidenz im Vergleich zum „best medical treatment“ und CAS (Karotisstenting) aktuell den Goldstandard dar. Bei entsprechender geeigneter Aneurysmamorphologie ist die endovaskuläre Aneurysmaausschaltung die Therapie der Wahl. Bei Patienten, die aufgrund Ihrer Komorbidität von der offen chirurgischen Aneurysmaausschaltung ausgeschlossen werden und eine Lebenserwartung von weniger als 4 Jahren haben, sollte die konservative Therapie in Erwägung gezogen werden. Die Wertigkeit der peripheren Bypasschirurgie ist aufgrund der signifikant reduzierten Lebenserwartung nach einer Major-Amputation mit Ausnahme der Patienten im Alter > 90 Jahre als hoch einzustufen.
Abstract
Due to the increasingly aging populations of the industrialised countries, the prevalence of vascular disorders is increasing, with an emerging patient subgroup of 80 years and older (octogenarians), often multi-morbid with an increased risk of anaesthesiological and surgical complications. This review article presents evidence-based indications for vascular surgery in the elderly (> 80 years), and the influence of advanced age on surgical results. Guidelines for daily practice were drawn from a thorough analysis of current treatment recommendations for three vascular disorders (carotid artery stenosis, abdominal aortic aneurysm, and peripheral arterial disease) with the aim of assisting the primary care physician in deciding upon the therapeutic management. In summary, evidence indicates that CEA (carotid endarterectomy) is the gold standard therapy for carotid artery stenosis, as opposed to the “best medical treatment” and CAS (carotid artery stenting). With suitable morphology of the aneurysm, endovascular aneurysm repair (EVAR) is the therapy of choice for abdominal aortic aneurysm (AAA). In elderly patients unfit for open repair and with a life expectancy of less than 4 years, EVAR does not offer any survival benefit compared with no intervention. In such patients, conservative therapy should be taken into consideration. Due to the significantly reduced life expectancy after a major amputation, the value of infrainguinal revascularisation is high, with the exception of patients aged > 90 years.
-
Literatur
- 1 Statisitisches Bundesamt. Pressemitteilung Statistisches Bundesamt vom 06.06.2003. Im Internet: www.destatis.de/presse/deutsch/pm2003/p2300022.htm Stand: 25.11.2009
- 2 Peeters A, Mamun AA, Willekens F. et al. A cardiovascular life history. A life course analysis of the original Framingham Heart Study cohort. Eur Heart J 2002; 23: 458-466
- 3 Fleisher LA, Beckman JA, Brown KA. et al. ACC / AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary: A Report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 2007; 116: 1971-1996
- 4 Dripps RD, Lamont A, Eckenhoff JE. The role of anesthesia in surgical mortality. JAMA 1961; 178: 261-266
- 5 Goldman L, Caldera DL, Nussbaum SR. et al. Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med 1977; 297: 845-850
- 6 Fine-Edelstein JS, Wolf PA, O’Leary DH. et al. Precursors of extracranial carotid atherosclerosis in the Framingham Study. Neurology 1994; 44: 1046-1050
- 7 Hillen T, Nieczaj R, Munzberg H. et al. Carotid atherosclerosis, vascular risk profile and mortality in a population-based sample of functionally healthy elderly subjects: the Berlin ageing study. J Intern Med 2000; 247: 679-688
- 8 No authors listed Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998; 351: 1379-1387
- 9 Kita MW. Carotid endarterectomy in symptomatic carotid stenosis: NASCET comparative results at 30 months of follow-up. J Insur Med 1992; 24: 42-46
- 10 Rothwell PM, Eliasziw M, Gutnikov SA. et al. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004; 363: 915-924
- 11 Naylor AR. Occam’s razor: Intervene early to prevent more strokes!. J Vasc Surg 2008; 48: 1053-1059
- 12 Naylor AR, Rothwell PM, Bell PR. Overview of the principal results and secondary analyses from the European and North American randomised trials of endarterectomy for symptomatic carotid stenosis. Eur J Vasc Endovasc Surg 2003; 26: 115-129
- 13 Alamowitch S, Eliasziw M, Algra A. et al. Risk, causes, and prevention of ischaemic stroke in elderly patients with symptomatic internal-carotid-artery stenosis. Lancet 2001; 357: 1154-1160
- 14 [no authors listed] Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995; 273: 1421-1428
- 15 Halliday A, Mansfield A, Marro J. et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004; 363: 1491-1502
- 16 Alozairi O, MacKenzie RK, Morgan R. et al. Carotid endarterectomy in patients aged 75 and over: early results and late outcome. Eur J Vasc Endovasc Surg 2003; 26: 245-249
- 17 Coyle KA, Smith 3rd RB, Salam AA. et al. Carotid endarterectomy in the octogenarian. Ann Vasc Surg 1994; 8: 417-420
- 18 Gough MJ, Bodenham A, Horrocks M. et al. GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery. Trials 2008; 9: 28-28
- 19 Ockert SSH, Schumacher H, Böckler D. et al. Desobliterierende Karotischirurgie bei über 80-Jährigen: eine effektive und sichere Schlaganfallprophylaxe. Gefässchirurgie 2005; 10: 168-172
- 20 Schneider JR, Droste JS, Schindler N. et al. Carotid endarterectomy in octogenarians: comparison with patient characteristics and outcomes in younger patients. J Vasc Surg 2000; 31: 927-935
- 21 Tangkanakul C, Counsell C, Warlow C. Local versus general anaesthesia for carotid endarterectomy. Cochrane Database Syst Rev 2000: CD000126
- 22 O’Hara PJ, Hertzer NR, Mascha EJ. et al. Carotid endarterectomy in octogenarians: early results and late outcome. J Vasc Surg 1998; 27: 860-869 discussion 870–861
- 23 Rerkasem K, Rothwell PM. Local versus general anesthetic for carotid endarterectomy. Stroke 2009; 40: e584-e585
- 24 Eckstein HH, Ringleb P, Allenberg JR. et al. Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial. Lancet Neurol 2008; 7: 893-902
- 25 Usman AA, Tang GL, Eskandari MK. Metaanalysis of procedural stroke and death among octogenarians: carotid stenting versus carotid endarterectomy. J Am Coll Surg 2009; 208: 1124-1131
- 26 Torsello G, Can A, Schumacher S. Das Bauchaortenaneurysma. Gefäßchirurgie 2005; 10: 139-152
- 27 Fichtner-Seigl SL-A, Debus ES. Überleben, Komplikationen und Risikofaktoren von rupturierten abdominellen Aortenaneurysmen. Gefäßchirurgie 2003; 8: 200-205
- 28 Gollackner B, Teufelsbauer H, Huk I. et al. Das abdominelle Aortenaneurysma: Indikation – Therapie – Ergebnisse. Z Gefäßmed 2006; 3: 4-8
- 29 Schermerhorn ML, Cronenwett JL. Abdominal aortic and iliac aneurysms. In: Rutherford RB, Cronenwett JL, Gloviczki P, et al., editors. Rutherford Vascular Surgery. 6th ed. Philadelphia: Elsevier 2005: 1403–1452
- 30 Bockler D, Mansmann U, Krauss M. et al. Endovaskuläre Aneurysmachirurgie beim alten Menschen – Methode der ersten Wahl?. Zentralbl Chir 2007; 132: 198-204
- 31 Lobato AC, Rodriguez-Lopez J, Malik A. et al. Impact of endovascular repair for abdominal aortic aneurysms in octogenarians. Ann Vasc Surg 2001; 15: 525-532
- 32 Sicard GA, Rubin BG, Sanchez LA. et al. Endoluminal graft repair for abdominal aortic aneurysms in high-risk patients and octogenarians: is it better than open repair?. Ann Surg 2001; 234: 427-435 discussion 435–437
- 33 Greenhalgh RM, Brown LC, Kwong GP. et al. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomised controlled trial. Lancet 2004; 364: 843-848
- 34 Dardik A, Lin JW, Gordon TA. et al. Results of elective abdominal aortic aneurysm repair in the 1990s: A population-based analysis of 2335 cases. J Vasc Surg 1999; 30: 985-995
- 35 Lederle FA, Wilson SE, Johnson GR. et al. Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1437-1444
- 36 United Kingdom Small Aneurysm Trial Participants. Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1445-1452
- 37 Vemuri C, Wainess RM, Dimick JB. et al. Effect of increasing patient age on complication rates following intact abdominal aortic aneurysm repair in the United States. J Surg Res 2004; 118: 26-31
- 38 Kazmers A, Perkins AJ, Jacobs LA. Outcomes after abdominal aortic aneurysm repair in those > or = 80 years of age: recent Veterans Affairs experience. Ann Vasc Surg 1998; 12: 106-112
- 39 Haug ES, Romundstad P, Aune S. et al. Elective open operation for abdominal aortic aneurysm in octogenarians – survival analysis of 105 patients. Eur J Vasc Endovasc Surg 2005; 29: 489-495
- 40 Hollier LH, Taylor LM, Ochsner J. Recommended indications for operative treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the Society for Vascular Surgery and the North American Chapter of the International Society for Cardiovascular Surgery. J Vasc Surg 1992; 15: 1046-1056
- 41 Currie IC, Scott DJ, Robson AK. et al. Quality of life of octogenarians after aneurysm surgery. Ann R Coll Surg Engl 1992; 74: 269-273
- 42 Conway KP, Byrne J, Townsend M. et al. Prognosis of patients turned down for conventional abdominal aortic aneurysm repair in the endovascular and sonographic era: Szilagyi revisited?. J Vasc Surg 2001; 33: 752-757
- 43 Zarins CK, White RA, Schwarten D. et al. AneuRx stent graft versus open surgical repair of abdominal aortic aneurysms: multicenter prospective clinical trial. J Vasc Surg 1999; 29: 292-305 discussion 306–308
- 44 Moore WS, Kashyap VS, Vescera CL. et al. Abdominal aortic aneurysm: a 6-year comparison of endovascular versus transabdominal repair. Ann Surg 1999; 230: 298-306 discussion 306–308
- 45 Matsumura JS, Brewster DC, Makaroun MS. et al. A multicenter controlled clinical trial of open versus endovascular treatment of abdominal aortic aneurysm. J Vasc Surg 2003; 37: 262-271
- 46 Makaroun MS, Chaikof E, Naslund T. et al. Efficacy of a bifurcated endograft versus open repair of abdominal aortic aneurysms: a reappraisal. J Vasc Surg 2002; 35: 203-210
- 47 Carpenter JP, Baum RA, Barker CF. et al. Durability of benefits of endovascular versus conventional abdominal aortic aneurysm repair. J Vasc Surg 2002; 35: 222-228
- 48 Cao P, Verzini F, Parlani G. et al. Clinical effect of abdominal aortic aneurysm endografting: 7-year concurrent comparison with open repair. J Vasc Surg 2004; 40: 841-848
- 49 Arko FR, Hill BB, Olcott C. et al. Endovascular repair reduces early and late morbidity compared to open surgery for abdominal aortic aneurysm. J Endovasc Ther 2002; 9: 711-718
- 50 Endovascular aneurysm repair and outcome in patients unfit for open repair of abdominal aortic aneurysm (EVAR trial 2): randomised controlled trial. Lancet 2005; 365: 2187-2192
- 51 Minor ME, Ellozy S, Carroccio A. et al. Endovascular aortic aneurysm repair in the octogenarian: is it worthwhile?. Arch Surg 2004; 139: 308-314
- 52 Botsios S, Schmidt A, Klaeffling C. et al. Die endovaskuläre Behandlung von Bauchaortenaneurysmen bei älteren Patienten (≥ 80 Jahre). Zentralbl Chir 2009; 134: 325-330
- 53 Diehm C, Schuster A, Allenberg JR. et al. High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study. Atherosclerosis 2004; 172: 95-105
- 54 Criqui MH, Langer RD, Fronek A. et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 1992; 326: 381-386
- 55 Adam DJ, Beard JD, Cleveland T. et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet 2005; 366: 1925-1934
- 56 Ouriel K, Fiore WM, Geary JE. Limb-threatening ischemia in the medically compromised patient: amputation or revascularization?. Surgery 1988; 104: 667-672
- 57 Taylor SM, Kalbaugh CA, Blackhurst DW. et al. Preoperative clinical factors predict postoperative functional outcomes after major lower limb amputation: an analysis of 553 consecutive patients. J Vasc Surg 2005; 42: 227-235
- 58 Taylor SM, Cull DL, Kalbaugh CA. et al. Critical analysis of clinical success after surgical bypass for lower-extremity ischemic tissue loss using a standardized definition combining multiple parameters: a new paradigm of outcomes assessment. J Am Coll Surg 2007; 204: 831-838 discussion 838–839
- 59 Bradbury AW, Adam DJ, Bell J. et al. Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: Analysis of amputation free and overall survival by treatment received. J Vasc Surg 2010; 51: 18S-31S
- 60 Nehler MR, Moneta GL, Edwards JM. et al. Surgery for chronic lower extremity ischemia in patients eighty or more years of age: operative results and assessment of postoperative independence. J Vasc Surg 1993; 18: 618-624 discussion 624–626
- 61 Pomposelli Jr FB, Arora S, Gibbons GW. et al. Lower extremity arterial reconstruction in the very elderly: successful outcome preserves not only the limb but also residential status and ambulatory function. J Vasc Surg 1998; 28: 215-225
- 62 Edwards WH, Mulherin Jr JL, Rogers DM. Vascular reconstruction in the octogenarian. South Med J 1982; 75: 648-652
- 63 Scher LA, Veith FJ, Ascer E. et al. Limb salvage in octogenarians and nonagenarians. Surgery 1986; 99: 160-165
- 64 O’Mara CS, Kilgore Jr TL, McMullan MH. et al. Distal bypass for limb salvage in very elderly patients. Am Surg 1987; 53: 66-70
- 65 Cogbill TH, Landercasper J, Strutt PJ. et al. Late results of peripheral vascular surgery in patients 80 years of age and older. Arch Surg 1987; 122: 581-586
- 66 Friedman SG, Kerner BA, Friedman MS. et al. Limb salvage in elderly patients. Is aggressive surgical therapy warranted?. J Cardiovasc Surg (Torino) 1989; 30: 848-851
- 67 Hnath J, Roddy SP, Darling 3rd RC. et al. Comparative results of open lower extremity revascularization in nonagenarians. J Vasc Surg 2009; 49: 1459-1463 discussion 1463–1464