Subscribe to RSS
DOI: 10.1055/s-0030-1262400
© Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Neue Ansatzpunkte zum Einsatz der Artischocke bei Diabetes mellitus Typ 2
Publication History
Publication Date:
08 November 2010 (online)
![](https://www.thieme-connect.de/media/phyto/201005/lookinside/thumbnails/10.1055-s-0030-1262400-1.jpg)
Zusammenfassung
Drogen mit dem Anspruch, als Antidiabetika zu wirken, sind in der Volksmedizin weit verbreitet. Ein Nachweis ihrer Wirkung fehlt jedoch oft. Basierend auf den Kenntnissen über polyphenolische alpha-Amylasehemmstoffe aus Pflanzen untersuchten wir Artischockenzubereitungen auf diese Wirkung. Zusammen mit der Fähigkeit, die postprandialen Blutzuckerspitzen zu vermindern und den Effekten auf den Lipidstoffwechsel könnten Artischockenzubereitungen als adjuvante Phytotherapeutika zur Beeinflussung der Stoffwechsellage beim metabolischen Syndrom eingesetzt werden.
Summary
Type 2 diabetes: a rationale indication for artichoke?
Antidiabetics of plant origin are commonly used. However, a proof of their efficacy or their mode of action is often missing. Based on the knowledge about polyphenolic inhibitors of alpha-amylase from plants we selected artichoke preparations for investigating the alpha-amylase inhibiting properties. Due to their ability to lower the postprandial blood glucose level in addition to its lipid-lowering effect, artichoke might be a useful adjuvant drug to influence the metabolic condition in case of metabolic syndrome.
Schlüsselwörter
alpha-Amylasehemmer - Diabetes - Arzneipflanzen - Artischocke
Key words
Inhibitors of alpha-Amylase - diabetes - herbal medicinal plants - artichoke - metabolic syndrome
Literatur
- r1 [Anonymous]. Screening for Type 2 Diabetes: Report of a World Health Organization and International Diabetes Federation meeting. Geneva; 2003 Document WHO/NMH/MNC/03.1
- r2 Tominaga M. Igarashi K. Eguchi H. , et al. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care. 1999; 22 920-924
- r3 Hanefeld M. Koehler C. Schaper F. , et al. Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in non-diabetic individuals. Atherosclerosis. 1999; 144 229-235
- r4 Lasek R. Müller-Oehrlinghausen B. Hrsg. Therapieempfehlungen der Arzneimittelkommission der deutschen Ärzteschaft: Diabetes mellitus. 1. Aufl. 2002: 13-17 http://www.akdae.de
- r5 Bischoff H. Pharmacology of alpha-glucosidase inhibition. Eur J Clin Invest. 1994; 24 ((Suppl. 3)) 3-10
- r6 Chiasson JL. Josse RG. Gomis R. , et al. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet. 2002; 359 2072-2077
- r7 Hanefeld M. Schaper E. Acarbose: oral antidiabetes drug with additional cardiovascular benefits. Expert Rev Cardiovasc Ther. 2008; 6 153-163
- r8 Bruce KD. Byrne CD. The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J. 2009; 85 614-621
- r9 Melzig MF. Funke I. Pflanzliche alpha-Amylasehemmer – eine Möglichkeit zur Phytotherapie bei Diabetes mellitus Typ II?. Wien Med Wochenschr. 2007; 157 320-324
- r10 Wegener T. Schmidt M. Artischockenblätterextrakt – Lipidsenkung auf pflanzlicher Basis. Ärztezeitschrift für Naturheilverfahren. 1995; 36 378-389
- r11 Holtmann G. Adam B. Haag S. , et al. Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a sixweek placebo-controlled, double-blind, multicentre trial. Aliment Pharmacol Therap. 2003; 18 1099-1105
- r12 Adzet T. Camarasa J. Laguna JC. Hepatoprotective activity of polyphenolic compounds from Cynara Scolymus against CCl4 toxicity in isolated rat hepatocytes. J Nat Prod. 1987; 50 612-617
- r13 Brand N. Die Artischocke – eine Dekade interdisziplinärer Forschung. Z Phytother. 1999; 20 292-302
- r14 Wegener T. Fintelmann V. Pharmakologische Eigenschaften und therapeutisches Profil der Artischocke (Cynara scolymus L.). Wien Med Wschr. 1999; 149 241-247
- r15 Thompson Coon JS. Ernst E. Herbs for serum cholesterol reduction: a systematic view. J Fam Pract. 2003; 52 468-478
- r16 Gebhardt R. Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extracts. J Pharmacol Exp Therap. 1998; 286 1122-1128
- r17 Bundy R. Walker AF. Middleton RW. , et al. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial. Phytomedicine. 2008; 15 668-675
- r18 Englisch W. Becker C. Unkauf M. , et al. Efficacy of Artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittelforschung. 2000; 50 260-265
- r19 Lupattelli G. Marchesi S. Lombardini R. , et al. Artichoke juice improves endothelial function in hyperlipidemia. Life Sci. 2004; 76 775-782
- r20 Funke I. Melzig MF. Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay. Pharmazie. 2005; 60 796-797
- r21 Tadera K. Minami Y. Takamatsu K. Matsuoka TJ. Inhibition of alpha-glucosidase and alphaamylase by flavonoids. Nutr Sci Vitaminol (Tokyo). 2006; 52 149-153
- r22 Rohn S. Rawel HM. Kroll J. Inhibitory Effects of plant phenols on the activity of selected enzymes. J Agric Food Chem. 2002; 59 3566-3571
- r23 McDougall GJ. Stewart D. The inhibitory effects of berry polyphenols on digestive enzymes. BioFactors. 2005; 23 189-195
- r24 Kwon YI. Vattem DA. Shetty K. Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac J Clin Nutr. 2006; 15 107-108
- r25 Olthof MR. Hollman PCH. Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001; 131 66-71
- r26 Plumb GW. Garcia-Conesa MT. Kroon PA. , et al. Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora. J Sci Food Agric. 1999; 79 390-392
- r27 , IFCC – International Federation of Clinical Chemistry: IFCC methods for measurement of catalytic concentration of enzymes. Part 9. IFCC method for α-amylase [1,4-α-D-glucan 4-glucanohydrolase, EC 3.2.1.1]. Clin Chim Acta. 1999; 281 S5-S39
- r28 Soor SK. Hincke MT. Microplate reader-based kinetic determination of alpha-amylase activity: application to quantitation of secretion from rat parotid acini. Anal Biochem. 1990; 188 187-191
- r29 Gella FJ. Gubern G. Vidal R. Canalias F. Determination of total and pancreatic alpha-amylase in human serum with 2-Chloro-4-nitrophenyl-alpha-D-maltotrioside as substrate. Clin Chim Acta. 1997; 259 147-160
- r30 Hinou J. Harvala C. Philianos S. Substances polyphénoliques des feuilles de Cynara scolymus L. Ann Pharm Fr. 1989; 47 95-98
- r31 Brand N. Cynara scolymus L. – Die Artischocke. Z Phytother. 1990; 11 169-175
- r32 Schütz K. Kammerer D. Carle R. Schieber A. Identification and quantification of caffeoylquinic acids and flavonoids from artichoke (Cynara scolymus L.) heads, juice, and pomace by HPLC-DAD-ESI/MS. J Agric Food Chem. 2004; 52 4090-4096
- r33 Wang M. Simon E. Aviles IF. , et al. Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). J Agric Food Chem. 2003; 51 601-608
- r34 Llorach R. Espín JC. Tomás-Barberán FA. Ferreres F. Artichoke (Cynara scolymus L.) byproducts as a potential source of healthpromoting antioxidant phenolics. J Agric Food Chem. 2002; 50 3458-3464
- r35 Fritsche J. Beindorff CM. Dachtler M. Zhang H. Lammers JG. Isolation, characterization and determination of minor artichoke (Cynara scolymus L.) leaf extract compounds. Eur Food Res Technol. 2002; 215 149-157
- r36 Funke I. Untersuchungen zur Beeinflussung der alpha-Amylase-Aktivität durch Pflanzenextrakte und polyphenolische Reinstoffe unter besonderer Berücksichtigung des Einflusses von Cynara cardunculus L. ssp. flavescens Wikl. und seiner Inhaltsstoffe [Dissertation]. Berlin; Freie Universität 2007
- r37 Funke I. Melzig MF. Pflanzliche alpha-Amylase Hemmstoffe. Diabetologie & Stoffwechsel. 2008; 3 , S76/Abstract 218
Prof. Dr. Matthias F. Melzig
Institut für Pharmazie der Freien Universität
Berlin
Königin-Luise-Str. 2+4
14195 Berlin
Email: melzig@zedat.fu-berlin.de
Online