RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2011(7): 0746-0746
DOI: 10.1055/s-0030-1260642
DOI: 10.1055/s-0030-1260642
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium-Catalyzed Asymmetric Cyclizations of γ-Alkynylaldehydes
K. Masuda, N. Sakiyama, R. Tanaka, K. Noguchi, K. Tanaka*
Tokyo University of Agriculture and Technology, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. Juni 2011 (online)
Significance
The authors report a rhodium(I)-catalyzed asymmetric cyclization of γ-alkynylaldehydes and acyl phosphonates via C-P or C-H bond cleavage with excellent enantioselectivities. Based on ligand choice, both C-H and C-P bond cleavage products can be formed exclusively in fair to good yields and generally outstanding asymmetric induction. The authors propose several mechanistic possibilities, but indicate that further studies are needed in order to elucidate the reaction mechanism.