Synlett 2011(10): 1381-1384  
DOI: 10.1055/s-0030-1260585
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Synthesis of α-Keto Esters from Ethylbenzenes Using 48% Aqueous HBr by Aerobic Visible Light Photooxidation

Norihiro Tada, Kazunori Ban, Tomoya Nobuta, Shin-ichi Hirashima, Tsuyoshi Miura, Akichika Itoh*
Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan
Fax: +81(58)2308105; e-Mail: itoha@gifu-pu.ac.jp;
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Publication History

Received 7 February 2011
Publication Date:
26 May 2011 (online)

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Abstract

We report that ethylbenzenes can be directly oxidized to the corresponding α-keto esters with molecular oxygen in the presence of 48% aqueous HBr under visible light irradiation. This synthetic procedure is the first example for direct preparation of the corresponding α-keto esters from ethylbenzenes.

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