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Synfacts 2011(7): 0777-0777
DOI: 10.1055/s-0030-1260496
DOI: 10.1055/s-0030-1260496
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Addition of Arylboronic Acids to Isatins
Z. Liu, P. Gu, M. Shi*, P. McDowell, G. Li*
Shanghai Institute of Organic Chemistry, P. R. of China and Texas Tech University, Lubbock, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. Juni 2011 (online)
Significance
Herein, a new catalytic system for the enantioselective arylation of isatins with arylboronic acids is reported. A chiral cationic C 2-symmetrical N-heterocyclic carbene Pd²+ diaqua complex is used as catalyst. The mild and convenient reaction conditions give the corresponding products in high yields and generally high enantioselectivities.